{"id":"W2050867219","doi":"10.1074/jbc.m607405200","title":"The Role of the GX9GX3G Motif in the Gating of High Voltage-activated Ca2+ Channels","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Gating; Motif (music); Chemistry; Biophysics; Cell biology; Biology; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004540414,0.00008684938,0.0001356643,0.000009155842,0.00006987367,0.00001018384,0.0002922349,0.0001605584,0.000015202],"category_scores_gemma":[0.0002553614,0.0000370272,0.0001418667,0.0001213444,0.0001524211,0.000003007416,0.00005169958,0.0001754317,1.813648e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001196724,"about_ca_system_score_gemma":0.0000325815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002198963,"about_ca_topic_score_gemma":0.000001832472,"domain_scores_codex":[0.9991532,0.00007666399,0.0004063167,0.00008946117,0.0001549634,0.0001193867],"domain_scores_gemma":[0.999126,0.00006917141,0.0004800339,0.0001597788,0.0001475395,0.00001749009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009297497,0.00006072091,0.003013358,0.000006506001,0.00001383837,5.65657e-7,0.00001930953,0.0009174293,0.9949514,0.00004387451,0.0001963178,0.0006836814],"study_design_scores_gemma":[0.0002710565,0.00008731988,0.009838209,0.00001946267,0.000005985615,0.00003021729,0.0003948602,0.0001012937,0.9847241,0.0009206703,0.003559589,0.00004721087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983414,0.0004616106,0.0001243016,0.0002769615,0.0001367748,0.00005772306,0.000004996194,0.000001352945,0.0005948847],"genre_scores_gemma":[0.9992869,0.00005408558,0.00002165712,0.00003907752,0.0004561416,0.000002166126,0.000009794474,0.000003934449,0.0001262195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0102273,"threshold_uncertainty_score":0.1509925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01067109889232864,"score_gpt":0.2205511078200181,"score_spread":0.2098800089276894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}