{"id":"W2050912869","doi":"10.1074/jbc.m109.047290","title":"Characterization of an Asymmetric Occluded State of P-glycoprotein with Two Bound Nucleotides","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Nucleotide; ATP hydrolysis; Chemistry; ATP-binding cassette transporter; Adenosine triphosphate; Biochemistry; Stereochemistry; Walker motifs; Binding site; Dimer; ATPase; Enzyme; Transporter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008452538,0.0001582611,0.0001991507,0.00008275339,0.0001046798,0.0003410366,0.0003165341,0.0003065741,0.0004542722],"category_scores_gemma":[0.0003778075,0.0001226566,0.0001213965,0.0001124476,0.0002459173,0.0002545056,0.0001787975,0.0004313203,0.0001068969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001879742,"about_ca_system_score_gemma":0.00009122341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004198297,"about_ca_topic_score_gemma":0.0002104181,"domain_scores_codex":[0.9998677,0.00001627959,0.000008504136,0.0000320078,0.00005065062,0.00002487201],"domain_scores_gemma":[0.9998391,0.00003531542,0.00005243732,0.00002166448,0.00002074066,0.0000307686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009356656,0.00002862362,0.0006196392,0.00002056443,0.000006796483,0.0001964265,0.00004356722,0.0001256152,0.9977622,0.0002222571,0.00003350058,0.0008470881],"study_design_scores_gemma":[0.0000317634,0.0004125093,0.01545351,0.00000663257,0.00003437024,0.001632826,0.000105703,0.009786235,0.9699259,0.0003469846,0.002240725,0.0000227144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978632,0.0001393953,0.001582153,0.00003250492,0.000003321183,0.000006400892,0.00005691766,0.00001306807,0.0003030074],"genre_scores_gemma":[0.9984669,0.00008402738,0.0009015601,0.00002549809,0.000003910773,0.00001000441,0.0002286991,0.000007827452,0.000271538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004542722,"threshold_uncertainty_score":0.00151968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01122775915376555,"score_gpt":0.2454310828585538,"score_spread":0.2342033237047882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}