{"id":"W2050933694","doi":"10.1007/s00109-007-0172-7","title":"The proprotein convertases are potential targets in the treatment of dyslipidemia","year":2007,"lang":"en","type":"review","venue":"Journal of Molecular Medicine","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":158,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Clinical Research Institute","funders":"","keywords":"Proprotein Convertases; PCSK9; Kexin; LDL receptor; Furin; Proprotein convertase; Biology; Biochemistry; Cell biology; Cholesterol; Lipoprotein; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001032656,0.0002809892,0.0009778101,0.0001154689,0.00004805763,0.000006768823,0.0003775808,0.0002691466,0.00001307251],"category_scores_gemma":[0.00009913724,0.0001210999,0.0005558289,0.0001513816,0.0001975117,0.000001916952,0.00001070601,0.0002551374,7.548558e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003881356,"about_ca_system_score_gemma":0.0001777594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001380875,"about_ca_topic_score_gemma":0.00002766359,"domain_scores_codex":[0.9978527,0.0002737973,0.001051989,0.000168667,0.000444319,0.0002084591],"domain_scores_gemma":[0.9982864,0.00004798232,0.001091762,0.0003547328,0.0001541572,0.00006492979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005655024,0.0007482372,0.00006047823,0.003892888,0.001677379,0.002811287,0.0003812142,0.00002095793,0.06190909,0.00008022796,0.0007223363,0.9271304],"study_design_scores_gemma":[0.0008114725,0.001613339,0.00003425774,0.001381384,0.001169354,0.0002154317,0.0001327309,0.000001026065,0.002180028,0.00001880815,0.9923249,0.0001172434],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001377378,0.9945796,0.002861056,0.0002834544,0.0002609199,0.0005801942,0.000008076288,9.320317e-7,0.00004839676],"genre_scores_gemma":[0.003248547,0.9955921,0.00004611096,0.00007835368,0.0006044821,0.00001292444,0.0003268798,0.00002471437,0.00006585108],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9916026,"threshold_uncertainty_score":0.4938309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02482470524428022,"score_gpt":0.3122645859592421,"score_spread":0.2874398807149618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}