{"id":"W2050954841","doi":"10.1038/cr.2011.128","title":"The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation","year":2011,"lang":"en","type":"article","venue":"Cell Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal; Université Laval; Hôtel-Dieu de Québec; McGill University; Jewish General Hospital","funders":"National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Leukemia and Lymphoma Society","keywords":"Biology; Rad50; DNA damage; RAD51; Exonuclease; DNA repair; DNA; Cell biology; Molecular biology; Homologous recombination; Non-homologous end joining; DNA-binding protein; Genetics; Gene; DNA polymerase; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007937815,0.0000777785,0.0000552027,0.00003835122,0.0003663814,0.00008057956,0.0001394657,0.0001113138,0.00001287783],"category_scores_gemma":[0.00004101153,0.00005717321,0.00002287237,0.0001041063,0.0001779038,0.000005736697,0.00009335062,0.0001269268,0.000005223515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008937737,"about_ca_system_score_gemma":0.00006623551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004738657,"about_ca_topic_score_gemma":0.00002860714,"domain_scores_codex":[0.9990891,0.00008545134,0.000118805,0.0002456747,0.0002004697,0.0002604476],"domain_scores_gemma":[0.9994129,0.00003456768,0.00003718811,0.0002341237,0.0002086247,0.00007261591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001689823,0.00002802855,0.001305345,0.00002765042,0.000007769604,5.376897e-7,0.0002300687,0.000003505322,0.9748087,0.00005306563,0.0001804141,0.02318597],"study_design_scores_gemma":[0.000354865,0.0001351054,0.009339233,0.000009155273,0.000003513253,6.398548e-7,0.0001434728,0.0001010923,0.9775519,0.0007765334,0.01151067,0.00007385353],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825454,0.002817392,0.0003143658,0.0001005191,0.00002716393,0.0001961389,0.000001072345,0.000005576567,0.01399241],"genre_scores_gemma":[0.995703,0.0009924043,0.0002161489,0.000006180176,0.0001078162,0.00001515866,0.00001873494,0.00001572573,0.002924777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02311211,"threshold_uncertainty_score":0.2817946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08121062890602172,"score_gpt":0.3311420756114058,"score_spread":0.2499314467053841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}