{"id":"W2050954841","doi":"10.1038/cr.2011.128","title":"The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation","year":2011,"lang":"en","type":"article","venue":"Cell Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":105,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Université de Montréal; Université Laval; Hôtel-Dieu de Québec; McGill University; Jewish General Hospital","funders":"National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Leukemia and Lymphoma Society","keywords":"Biology; Rad50; DNA damage; RAD51; Exonuclease; DNA repair; DNA; Cell biology; Molecular biology; Homologous recombination; Non-homologous end joining; DNA-binding protein; Genetics; Gene; DNA polymerase; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002462876,0.0004313583,0.0003361662,0.000261419,0.0004020791,0.000641094,0.0003840279,0.0005768203,0.003985155],"category_scores_gemma":[0.0003219837,0.0004310063,0.0003469427,0.0001136611,0.0004682558,0.000499989,0.0005898376,0.001083695,0.001882735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004074141,"about_ca_system_score_gemma":0.0001582876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000389698,"about_ca_topic_score_gemma":0.001027055,"domain_scores_codex":[0.999718,0.00005052909,0.00002021373,0.00008523992,0.00003995343,0.00008598853],"domain_scores_gemma":[0.9997588,0.00005112865,0.00006472693,0.00004426698,0.00001580189,0.00006522799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002028152,0.00001513921,0.0001813352,0.0000216957,0.000004201935,0.00007862922,0.00001350781,0.00007908223,0.9975943,0.000409569,0.00006027371,0.001339568],"study_design_scores_gemma":[0.000008016341,0.00005279822,0.002302465,0.000004278837,0.000004682053,0.0001602304,0.00002940721,0.0004792545,0.9953307,0.00009566643,0.001527285,0.000005178953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847497,0.002476137,0.008236185,0.0003560952,0.00009400812,0.00001984656,0.0002673852,0.000332417,0.003468249],"genre_scores_gemma":[0.992012,0.0003572477,0.003180606,0.00006788663,0.00001011093,0.00001085149,0.0002518985,0.00006948499,0.00404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003985155,"threshold_uncertainty_score":0.01333171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08121062890602172,"score_gpt":0.3311420756114058,"score_spread":0.2499314467053841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}