{"id":"W2050963795","doi":"10.1074/jbc.m708087200","title":"The Proinflammatory Cytokine, Interleukin-6, Up-regulates Calcium-sensing Receptor Gene Transcription via Stat1/3 and Sp1/3","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Vitamin D Research Studies","field":"Medicine","cited_by":154,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Royal Victoria Hospital","funders":"Canadian Institutes of Health Research; Cedars-Sinai Medical Center; Universität Wien; McGill University","keywords":"Calcium-sensing receptor; Proinflammatory cytokine; Parathyroid hormone; Endocrinology; Internal medicine; Reporter gene; STAT1; Molecular biology; Chemistry; Cytokine; Calcium; Receptor; Biology; Gene expression; Medicine; Inflammation; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001225744,0.0003916397,0.0002008827,0.000294891,0.00018137,0.0002585753,0.0001190532,0.0001775239,0.002128797],"category_scores_gemma":[0.0001031791,0.0001629232,0.0004933298,0.0002153924,0.0002002875,0.000132696,0.0002168166,0.0006261091,0.0006165481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002215532,"about_ca_system_score_gemma":0.000200608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00043519,"about_ca_topic_score_gemma":0.0006991986,"domain_scores_codex":[0.9997734,0.00003268782,0.00001832851,0.00004194778,0.000064308,0.0000691815],"domain_scores_gemma":[0.9999042,0.00001842794,0.00002317392,0.000008677541,0.00001676501,0.00002879295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001638691,0.00003695219,0.0004244487,0.00005745383,0.000004859727,0.00004844764,0.0000197487,0.00005056414,0.9975724,0.0000918451,0.0001184957,0.001410887],"study_design_scores_gemma":[0.00007198572,0.0004973517,0.01681059,0.00001783073,0.00003024739,0.0004495651,0.00008688652,0.002643576,0.9735768,0.0001491311,0.005656956,0.000008982031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830648,0.003572707,0.008067778,0.000240012,0.0001312471,0.00006392459,0.001453375,0.0002026017,0.003203513],"genre_scores_gemma":[0.9855381,0.002240791,0.005513872,0.0001404729,0.00004388505,0.0000849334,0.002105383,0.00002957965,0.004302871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002128797,"threshold_uncertainty_score":0.007121563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04221589021689757,"score_gpt":0.2870133680489754,"score_spread":0.2447974778320778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}