{"id":"W2050968102","doi":"10.1371/journal.pone.0051672","title":"Heterologous SUMO-2/3-Ubiquitin Chains Optimize IκBα Degradation and NF-κB Activity","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"Canadian Institutes of Health Research; Alzheimer Society; Department of Industry, Tourism and Trade","keywords":"Ubiquitin; SUMO protein; Proteasome; IκBα; IκB kinase; Cell biology; Ubiquitin ligase; Heterologous; NF-κB; Proteolysis; Biology; Chemistry; Gene silencing; Protein subunit; Molecular biology; Biochemistry; Signal transduction; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001624917,0.0003854776,0.0003137498,0.0001082046,0.0001483506,0.000379168,0.0001331447,0.0002294349,0.00114856],"category_scores_gemma":[0.00009590833,0.0001376932,0.0003287365,0.0001726998,0.0001958449,0.0002272396,0.0001884076,0.0004690487,0.0003869857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002448649,"about_ca_system_score_gemma":0.0001538799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002510826,"about_ca_topic_score_gemma":0.0003605761,"domain_scores_codex":[0.9998636,0.00002112144,0.00001507928,0.0000311311,0.00003831927,0.00003070106],"domain_scores_gemma":[0.999911,0.00001036165,0.00003021297,0.00001644464,0.000009706614,0.00002243319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005382687,0.0000155967,0.00006645672,0.00001664703,0.000003207897,0.000009743705,0.000003196116,0.00004253855,0.9993898,0.00003642691,0.000008658556,0.000353886],"study_design_scores_gemma":[0.000004111652,0.00006420846,0.0006330048,0.000001374989,0.000004874147,0.00006575883,0.000004332168,0.0001869834,0.9981613,0.00001856204,0.0008542187,0.000001223415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917055,0.001764388,0.005003123,0.0000572585,0.00003036519,0.00001902653,0.0003297476,0.00006715079,0.001023293],"genre_scores_gemma":[0.9941334,0.0007653518,0.002878577,0.00002637881,0.000008128605,0.00001359778,0.0004756242,0.00002637569,0.001672496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00114856,"threshold_uncertainty_score":0.003842294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04689719678774979,"score_gpt":0.2365484739070721,"score_spread":0.1896512771193224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}