{"id":"W2050987629","doi":"10.1016/j.nucmedbio.2004.02.010","title":"Impact on estrogen receptor binding and target tissue uptake of [18F]fluorine substitution at the 16α-position of fulvestrant (faslodex; ICI 182,780)","year":2004,"lang":"en","type":"article","venue":"Nuclear Medicine and Biology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Fulvestrant; Antiestrogen; Chemistry; Estrogen receptor; Estrogen; Pharmacology; Cancer research; Stereochemistry; Cancer; Internal medicine; Breast cancer; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002607268,0.0003109945,0.0003504645,0.0001456138,0.0001906142,0.000393229,0.000341658,0.0004056589,0.00251554],"category_scores_gemma":[0.0004533521,0.0002241253,0.0001896915,0.0001255,0.0003706713,0.0003579316,0.0001155092,0.0003464493,0.0004380786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004490305,"about_ca_system_score_gemma":0.0004696008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004295132,"about_ca_topic_score_gemma":0.002285639,"domain_scores_codex":[0.9998208,0.00004672757,0.000007805536,0.00003087573,0.00002071083,0.0000731998],"domain_scores_gemma":[0.9997808,0.0001010887,0.00004008586,0.00001893484,0.00001881322,0.00004033339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007100862,0.00009784733,0.000628896,0.00003281985,0.00002816603,0.0001065885,0.00004963733,0.0005002684,0.9873071,0.000158086,0.00007928,0.003910463],"study_design_scores_gemma":[0.0002366804,0.003542674,0.004107013,0.000005740266,0.00009810984,0.0003899458,0.00005301338,0.001579308,0.9880498,0.00005327769,0.00187294,0.00001153647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984849,0.0005734813,0.0001721069,0.00003634999,0.00001263464,0.000003122856,0.00007449313,0.00001482737,0.0006281718],"genre_scores_gemma":[0.9981393,0.0002905106,0.0001495512,0.00002362599,0.000006839704,0.000003471119,0.0001857825,0.00001879817,0.001182307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004295132,"threshold_uncertainty_score":0.008540273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0117529068675524,"score_gpt":0.2778818837914384,"score_spread":0.266128976923886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}