{"id":"W2050999393","doi":"10.1182/blood-2011-11-391474","title":"Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":334,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; BC Cancer Agency","funders":"National Cancer Institute; Canadian Institutes of Health Research; Ligue Genevoise Contre le Cancer; Terry Fox Foundation; Canada's Michael Smith Genome Sciences Centre","keywords":"Mantle cell lymphoma; Biology; Cyclin D1; Cancer research; Transcriptome; Mutation; Genetics; Indel; Gene; Lymphoma; Cell cycle; Single-nucleotide polymorphism; Genotype; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001318282,0.0001332404,0.0002151428,0.0001309787,0.0000322819,0.000006860488,0.00009625865,0.00008804407,0.000320338],"category_scores_gemma":[0.00003878868,0.0001278349,0.00007026201,0.0002424612,0.00004513484,0.00004365777,0.00001728946,0.0001119874,0.0001185547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001361103,"about_ca_system_score_gemma":0.0001684869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001271427,"about_ca_topic_score_gemma":0.00009029769,"domain_scores_codex":[0.9989632,0.00003651002,0.0002760635,0.0002553893,0.0001966865,0.000272094],"domain_scores_gemma":[0.9995082,0.00002749175,0.00005149646,0.0002483335,0.00005320651,0.0001112869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001751225,0.002241382,0.06060748,0.0003719444,0.00006585672,0.0002972931,0.01496568,0.000005772346,0.9153555,0.00004866613,0.0005763072,0.005288976],"study_design_scores_gemma":[0.01078782,0.001154326,0.3362386,0.000417369,0.0003695976,0.0001642418,0.001334131,0.0000643741,0.6462337,0.0009823721,0.001818715,0.0004346687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979122,0.0007269137,0.00003971138,0.0000759109,0.0003002844,0.0003650849,0.00001856783,0.00004898238,0.01930249],"genre_scores_gemma":[0.995356,0.00003232411,0.003628975,0.0001638414,0.00006389542,0.00006391682,0.00001436818,0.00002662166,0.0006501051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2756312,"threshold_uncertainty_score":0.5212954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04219781797124564,"score_gpt":0.2602862394829832,"score_spread":0.2180884215117375,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}