{"id":"W2051057601","doi":"10.1021/bm101396u","title":"Structure-Based Design of a Heptavalent Anthrax Toxin Inhibitor","year":2011,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Chemistry; Anthrax toxin; Bacillus anthracis; In vivo; Click chemistry; Combinatorial chemistry; Polyethylene glycol; Toxin; In vitro; Linker; Biochemistry; Recombinant DNA; Biology; Bacteria; Fusion protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001535788,0.0001717918,0.0001735454,0.00006780484,0.0000513782,0.00001342299,0.0002552466,0.0001670594,0.000223851],"category_scores_gemma":[0.00006507919,0.0001499183,0.0001031583,0.0001193521,0.0002132695,0.000002579769,0.00008533315,0.00004941249,0.00001020917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009767214,"about_ca_system_score_gemma":0.0001294735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000652296,"about_ca_topic_score_gemma":0.00001847439,"domain_scores_codex":[0.9988549,0.0001053094,0.0002396642,0.0003234981,0.0001832707,0.0002933958],"domain_scores_gemma":[0.9992911,0.000009537929,0.00008701452,0.0003769885,0.0001256677,0.0001096774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003526418,0.000116369,0.0004248895,0.00003352262,0.00003815601,0.00001066043,0.0000458312,0.0000041227,0.9956362,0.00007233997,0.0003510645,0.002914267],"study_design_scores_gemma":[0.0006157733,0.0006865285,0.00170843,0.00001662926,0.0000112456,0.000006873499,0.00001773513,0.00005904146,0.9953658,0.00008521741,0.0012484,0.0001783462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9747007,0.0006225437,0.0235752,0.0000199652,0.0001813067,0.0002898928,0.0001307523,0.00001372849,0.0004658663],"genre_scores_gemma":[0.9917946,0.00004566818,0.00785361,0.00005442237,0.0001029489,0.00001186556,0.00005455888,0.00002730283,0.00005504588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01709383,"threshold_uncertainty_score":0.6113492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03502058484052897,"score_gpt":0.2533569986036076,"score_spread":0.2183364137630786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}