{"id":"W2051057601","doi":"10.1021/bm101396u","title":"Structure-Based Design of a Heptavalent Anthrax Toxin Inhibitor","year":2011,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Bacillus and Francisella bacterial research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Chemistry; Anthrax toxin; Bacillus anthracis; In vivo; Click chemistry; Combinatorial chemistry; Polyethylene glycol; Toxin; In vitro; Linker; Biochemistry; Recombinant DNA; Biology; Bacteria; Fusion protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001217754,0.0002985502,0.0003152226,0.0002047164,0.000153622,0.0003857007,0.0003685406,0.0002534481,0.0007412194],"category_scores_gemma":[0.0001278338,0.0001887404,0.0001665557,0.0001370831,0.0002219416,0.0001575935,0.0001727308,0.0004228318,0.0004045131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006938081,"about_ca_system_score_gemma":0.0004576986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008407392,"about_ca_topic_score_gemma":0.001244975,"domain_scores_codex":[0.9999136,0.00001056383,0.00000747317,0.00002056974,0.00003119575,0.00001648703],"domain_scores_gemma":[0.999944,0.000006529114,0.00001685945,0.00000453074,0.000008739204,0.00001942521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001001521,0.00007747292,0.0001280901,0.00004147571,0.000007720059,0.00007954428,0.00001606162,0.005310371,0.9900439,0.0007516073,0.00005561953,0.003387981],"study_design_scores_gemma":[0.00006577841,0.0005176094,0.0004061306,0.000004776806,0.00002300741,0.0001288072,0.00001022904,0.01221794,0.982691,0.00007162651,0.003852791,0.00001034555],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9593847,0.001306706,0.03410807,0.000175261,0.00003816932,0.0002624634,0.0002104725,0.0002213442,0.004292747],"genre_scores_gemma":[0.9777837,0.0008225777,0.01755437,0.00006639755,0.000005387183,0.00007487137,0.0003090173,0.00002340574,0.003360272],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008407392,"threshold_uncertainty_score":0.00503397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03502058484052897,"score_gpt":0.2533569986036076,"score_spread":0.2183364137630786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}