{"id":"W2051066183","doi":"10.1074/jbc.m300671200","title":"Prostaglandin E2 Stimulates Bone Sialoprotein (BSP) Expression through cAMP and Fibroblast Growth Factor 2 Response Elements in the Proximal Promoter of the Rat BSP Gene","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Canadian Institutes of Health Research","funders":"","keywords":"Bone sialoprotein; Osteoblast; Molecular biology; Fibroblast; Biology; Prostaglandin E2; Transcription factor; Transfection; Internal medicine; Chemistry; Endocrinology; Cell culture; Gene; Osteocalcin; Medicine; Alkaline phosphatase; Genetics; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004623892,0.0001717623,0.0002399422,0.00001184444,0.00006282208,0.00003026512,0.0002330703,0.0001913778,0.00002741321],"category_scores_gemma":[0.001014123,0.00007909658,0.000126458,0.00008424593,0.0001797156,0.00001170272,0.00009746446,0.0001899284,1.839532e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009346681,"about_ca_system_score_gemma":0.0000794373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000114122,"about_ca_topic_score_gemma":3.061656e-7,"domain_scores_codex":[0.9986948,0.0003146446,0.0003873988,0.0002069132,0.0001942881,0.0002019528],"domain_scores_gemma":[0.99924,0.00004394922,0.00034407,0.000213693,0.00009708725,0.00006119128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001104512,0.0001866708,0.01679109,0.00004258685,0.00001417412,0.00001183669,0.00007828519,0.000001890691,0.9815813,0.000002710978,0.0001407225,0.00004427451],"study_design_scores_gemma":[0.001117523,0.0002917691,0.02222415,0.00006402095,0.00001205911,0.00008828063,0.0001212984,9.708785e-7,0.9745595,0.0001958302,0.001215897,0.000108634],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997722,0.00161722,0.0000353188,0.0002613507,0.00002962561,0.0002549773,0.0000424733,0.000001896802,0.00003514114],"genre_scores_gemma":[0.9989225,0.0001319807,0.0006609129,0.00008698952,0.0001013623,0.00001047834,0.00001003748,0.000007505008,0.00006823717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007021676,"threshold_uncertainty_score":0.3225465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01445951742156322,"score_gpt":0.2455495908944768,"score_spread":0.2310900734729136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}