{"id":"W2051075639","doi":"10.1016/j.ejmech.2010.07.051","title":"Synthesis of the steroidal glycoside (25R)-3β,16β-diacetoxy-12,22-dioxo-5α-cholestan-26-yl β-d-glucopyranoside and its anti-cancer properties on cervicouterine HeLa, CaSki, and ViBo cells","year":2010,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Natural product bioactivities and synthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Consejo Nacional de Ciencia y Tecnología","keywords":"HeLa; Chemistry; Apoptosis; Cytotoxic T cell; Cancer cell; DNA fragmentation; Programmed cell death; Fragmentation (computing); Glycoside; Cytotoxicity; Cell growth; Cell culture; Biochemistry; Cell; Molecular biology; Cancer; Stereochemistry; In vitro; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009905057,0.0005199094,0.000369945,0.0003110159,0.0002680082,0.0002350428,0.0003374464,0.0002117987,0.001765512],"category_scores_gemma":[0.00007318097,0.0001235926,0.0002664446,0.000392981,0.0001982927,0.0001652881,0.0002122823,0.0002922291,0.0006447899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002237481,"about_ca_system_score_gemma":0.0006295063,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001977501,"about_ca_topic_score_gemma":0.002241701,"domain_scores_codex":[0.9999518,0.000006142873,0.000004598632,0.000008676399,0.000007204906,0.00002149564],"domain_scores_gemma":[0.9999453,0.000004378728,0.000008315566,0.000007070802,0.000007990734,0.00002693647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002651383,0.00006854159,0.0002009238,0.0001082082,0.00001556497,0.0005981959,0.0000738405,0.0005523762,0.9867976,0.000472328,0.0001748566,0.01067242],"study_design_scores_gemma":[0.00007756309,0.001103729,0.002422991,0.00001114278,0.00004620638,0.0003742361,0.00006139369,0.0003433008,0.9860427,0.0001252485,0.009371111,0.00002037878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9707788,0.00522836,0.008606788,0.0002501732,0.0001293685,0.0002998684,0.00277934,0.0002007095,0.01172664],"genre_scores_gemma":[0.9816945,0.003389342,0.005432517,0.00007724345,0.00002956528,0.00007709493,0.001856292,0.00002432011,0.00741905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001977501,"threshold_uncertainty_score":0.005906224,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008637328271248471,"score_gpt":0.2079736875301143,"score_spread":0.1993363592588658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}