{"id":"W2051075639","doi":"10.1016/j.ejmech.2010.07.051","title":"Synthesis of the steroidal glycoside (25R)-3β,16β-diacetoxy-12,22-dioxo-5α-cholestan-26-yl β-d-glucopyranoside and its anti-cancer properties on cervicouterine HeLa, CaSki, and ViBo cells","year":2010,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Natural product bioactivities and synthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Consejo Nacional de Ciencia y Tecnología","keywords":"HeLa; Chemistry; Apoptosis; Cytotoxic T cell; Cancer cell; DNA fragmentation; Programmed cell death; Fragmentation (computing); Glycoside; Cytotoxicity; Cell growth; Cell culture; Biochemistry; Cell; Molecular biology; Cancer; Stereochemistry; In vitro; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007225318,0.0003106388,0.0004221783,0.00003739071,0.0001242431,0.00003995984,0.0004212691,0.0001153897,0.00006926854],"category_scores_gemma":[0.0003462356,0.0001970743,0.0001458097,0.00006008023,0.0003093655,0.00001936054,0.0002000565,0.0006164782,0.000001471691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001576629,"about_ca_system_score_gemma":0.00008310943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008624513,"about_ca_topic_score_gemma":0.000005708102,"domain_scores_codex":[0.9982677,0.0001713845,0.0005352679,0.0003479624,0.0003985156,0.000279216],"domain_scores_gemma":[0.9986655,0.00005870415,0.0005151822,0.0003728742,0.0001862585,0.0002014407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004249849,0.00005756009,0.0004930514,0.0002711218,0.0001233353,0.00004074078,0.0001163611,0.00000522045,0.988416,7.622851e-7,0.0006265976,0.009424265],"study_design_scores_gemma":[0.0006700445,0.0002304875,0.00269238,0.0004185637,0.0001134342,0.0004251549,0.0002434209,0.000009082484,0.9889196,0.000003002264,0.006052488,0.0002223116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922164,0.004756691,0.000005196883,0.001853042,0.000383064,0.0001102052,0.00003891375,0.000006640823,0.0006298638],"genre_scores_gemma":[0.9953915,0.002231872,0.0000865266,0.0002607955,0.001240121,0.000001709009,0.000001267426,0.00005461748,0.0007316252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009201953,"threshold_uncertainty_score":0.8036459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008637328271248471,"score_gpt":0.2079736875301143,"score_spread":0.1993363592588658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}