{"id":"W2051088451","doi":"10.1126/science.aaa5945","title":"The mutagenic chain reaction: A method for converting heterozygous to homozygous mutations","year":2015,"lang":"en","type":"article","venue":"Science","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":636,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; University of California, San Diego; National Institutes of Health; Ryerson University","keywords":"Genetics; Allele; Mutation; Biology; Mutant; Phenotype; Gene; Compound heterozygosity; Heterozygote advantage","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003657064,0.001651173,0.001306051,0.002261678,0.0009293667,0.001098781,0.001477292,0.001546724,0.003543012],"category_scores_gemma":[0.00264555,0.0016078,0.0007518962,0.001125066,0.001829786,0.0009647323,0.001638403,0.003731392,0.003309139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005008503,"about_ca_system_score_gemma":0.001112888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004548558,"about_ca_topic_score_gemma":0.001144507,"domain_scores_codex":[0.9965676,0.0009654251,0.0002812714,0.0008132997,0.001196405,0.0001758666],"domain_scores_gemma":[0.9982505,0.0006383217,0.000282501,0.0004008446,0.000278879,0.0001487943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001237328,0.0001098993,0.0003622696,0.0005514761,0.0000605441,0.0004681389,0.0002012647,0.0003867529,0.9428665,0.006613235,0.003515875,0.04474022],"study_design_scores_gemma":[0.00006699827,0.0003776066,0.0006011213,0.00009160504,0.00007871554,0.002389946,0.00004039525,0.00182641,0.9054716,0.001854386,0.08710701,0.0000942944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.01151235,0.003138233,0.977073,0.0004766471,0.0005291305,0.000839869,0.0003046925,0.001964694,0.00416139],"genre_scores_gemma":[0.09843422,0.01329197,0.8639286,0.0007649577,0.0002183608,0.002394954,0.00166397,0.000809475,0.01849353],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.003657064,"threshold_uncertainty_score":0.01934057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01990074780604358,"score_gpt":0.3763790497558547,"score_spread":0.3564783019498112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}