{"id":"W2051088451","doi":"10.1126/science.aaa5945","title":"The mutagenic chain reaction: A method for converting heterozygous to homozygous mutations","year":2015,"lang":"en","type":"article","venue":"Science","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":636,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; University of California, San Diego; National Institutes of Health; Ryerson University","keywords":"Genetics; Allele; Mutation; Biology; Mutant; Phenotype; Gene; Compound heterozygosity; Heterozygote advantage","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01990074780604358,"score_gpt":0.3763790497558547,"score_spread":0.3564783019498112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}