{"id":"W2051101327","doi":"10.1158/1538-7445.am10-2307","title":"Abstract 2307: Cellular expression of E-cadherin but not its plasma membrane localization is regulated by the PTEN/PI 3 Kinase pathway via transcription factors twist and snail","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"PTEN; Biology; Cadherin; Transfection; Epithelial–mesenchymal transition; Cancer research; Transcription factor; Cancer cell; Twist transcription factor; CDH1; Cell biology; Metastasis; Cell culture; Cell; Cancer; Signal transduction; PI3K/AKT/mTOR pathway; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004702857,0.0003092743,0.0001182571,0.0001754579,0.0001759216,0.0003283926,0.0001552832,0.0001383506,0.00455731],"category_scores_gemma":[0.00005188286,0.0001108403,0.000196291,0.0001836711,0.0001712301,0.0001558704,0.0002190871,0.0003692044,0.001386249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002210525,"about_ca_system_score_gemma":0.0002035069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008441447,"about_ca_topic_score_gemma":0.0007713307,"domain_scores_codex":[0.9999261,0.000006459667,0.000004766582,0.00001433838,0.00002109128,0.00002728975],"domain_scores_gemma":[0.9999517,0.000004769364,0.00001473244,0.000004026819,0.00000626801,0.00001833358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000856542,0.00001806152,0.0002197552,0.00004317422,0.000003179178,0.00008921384,0.000007386237,0.00002485965,0.9982193,0.0001789322,0.0001422879,0.0009680539],"study_design_scores_gemma":[0.00002248064,0.0001801918,0.01851566,0.00001144781,0.00001532198,0.0005366002,0.00005145202,0.001202775,0.9741818,0.000142145,0.005134257,0.00000585219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985333,0.001318709,0.002985078,0.0001442486,0.00003843396,0.0000281575,0.001929505,0.0002612497,0.007961639],"genre_scores_gemma":[0.9865941,0.0006986787,0.0008854789,0.00004904278,0.000008325009,0.00003370031,0.002410058,0.00002864927,0.009291889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00455731,"threshold_uncertainty_score":0.01524574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03114290087082192,"score_gpt":0.3052989621779676,"score_spread":0.2741560613071457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}