{"id":"W2051118426","doi":"10.1182/blood-2007-03-079699","title":"Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":161,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Institute of Infection and Immunity; University of British Columbia; Vancouver Coastal Health Research Institute; Vancouver General Hospital","funders":"","keywords":"PI3K/AKT/mTOR pathway; Phosphoinositide 3-kinase; Kinase; Cell biology; Phosphatase; Signal transduction; Chemistry; Inositol; Phosphorylation; Allosteric regulation; MAPK/ERK pathway; Biology; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001177025,0.0002946232,0.0001698403,0.0002062181,0.0001100344,0.0001782874,0.0001418381,0.0001599632,0.00133478],"category_scores_gemma":[0.0000956432,0.0001174465,0.000170354,0.0001679598,0.0001675848,0.0001232418,0.0001362474,0.0004425438,0.0004033489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003173405,"about_ca_system_score_gemma":0.0002473618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00032533,"about_ca_topic_score_gemma":0.001061409,"domain_scores_codex":[0.9999429,0.00001210882,0.000003272872,0.000008081108,0.00001710692,0.00001657026],"domain_scores_gemma":[0.9999686,0.00001050083,0.000007444708,0.000002938978,0.000003133596,0.000007479492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001706486,0.00009761674,0.0001274715,0.00007093348,0.000008434584,0.00006735409,0.00001109836,0.0002877264,0.9927539,0.0003428973,0.0002020266,0.005859898],"study_design_scores_gemma":[0.00006978722,0.000539616,0.00188012,0.000003805487,0.00001797497,0.000155796,0.000009601653,0.0007826296,0.992506,0.00005458759,0.003977144,0.00000301779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826538,0.006974616,0.004478069,0.0003147927,0.00004737838,0.0001201302,0.000386393,0.0001425959,0.004882372],"genre_scores_gemma":[0.9844472,0.006651647,0.003943386,0.0001144394,0.00002500506,0.0001113981,0.0005539213,0.0000156434,0.004137401],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00133478,"threshold_uncertainty_score":0.004465282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01049619468648742,"score_gpt":0.2261722355667041,"score_spread":0.2156760408802166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}