{"id":"W2051132383","doi":"10.1016/j.ijpharm.2006.11.055","title":"β-Aminoketones as prodrugs with pH-controlled activation","year":2006,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":false,"ca_institutions":"Trinity College","funders":"European Social Fund; Fundação para a Ciência e a Tecnologia","keywords":"Ketone; Chemistry; Amine gas treating; Adduct; Prodrug; Chalcone; Mannich reaction; Organic chemistry; Michael reaction; Combinatorial chemistry; Catalysis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002173564,0.0004927368,0.0002165651,0.0001990185,0.0001148429,0.000265621,0.0002830882,0.0003209338,0.001322435],"category_scores_gemma":[0.0001528861,0.0001963305,0.0001939454,0.0001425775,0.0002142883,0.000377154,0.0003153882,0.0004597772,0.0005703494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002208735,"about_ca_system_score_gemma":0.0001376003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002016342,"about_ca_topic_score_gemma":0.0002374278,"domain_scores_codex":[0.9998665,0.00002770841,0.00001434098,0.00002656945,0.0000262698,0.00003875004],"domain_scores_gemma":[0.9999402,0.00001461533,0.00001450725,0.000007801563,0.000009051741,0.00001377312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003211707,0.00004195191,0.00005774249,0.0001180672,0.000007095755,0.0002043843,0.00004862994,0.0008553534,0.9896753,0.001183335,0.0001293657,0.007357634],"study_design_scores_gemma":[0.00004001378,0.0002874905,0.000140308,0.000004173315,0.000006342691,0.0001079099,0.000006290049,0.0006763276,0.997085,0.0001321152,0.001507466,0.000006543062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9428873,0.004502621,0.0333658,0.0002411239,0.0002205973,0.000318559,0.0003377153,0.0006093234,0.01751691],"genre_scores_gemma":[0.9904297,0.00107206,0.00437415,0.00004457647,0.00001431781,0.00005689912,0.00009698752,0.00002642449,0.003884979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001322435,"threshold_uncertainty_score":0.004424036,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008603893340052302,"score_gpt":0.2985557342154782,"score_spread":0.2899518408754259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}