{"id":"W2051165614","doi":"10.1182/blood-2012-06-430645","title":"Darwinian evolution and tiding clones in multiple myeloma","year":2012,"lang":"en","type":"letter","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Multiple myeloma; Darwinism; Biology; Genetics; Cancer research; Computational biology; Evolutionary biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002590286,0.0005711319,0.001030417,0.0006219969,0.002437012,0.002593297,0.001611185,0.01856802,0.002283538],"category_scores_gemma":[0.011687,0.0004261995,0.0004912447,0.0005526593,0.003968386,0.00396824,0.001494874,0.02119025,0.00147625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002243593,"about_ca_system_score_gemma":0.0008495423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001143764,"about_ca_topic_score_gemma":0.002245754,"domain_scores_codex":[0.9985663,0.0005587135,0.0001101585,0.0002289655,0.0003778779,0.0001580447],"domain_scores_gemma":[0.9950746,0.003621668,0.0003042327,0.0001934173,0.0003978182,0.0004082299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000242723,0.00005461662,0.002500457,0.0002065412,0.00006839661,0.006271756,0.0004280655,0.0003475343,0.0007224001,0.01939321,0.9051563,0.06460815],"study_design_scores_gemma":[0.0003807019,0.0002205075,0.004416939,0.0004128621,0.0001123962,0.02178301,0.0008908335,0.003367821,0.0009571086,0.1382076,0.8291491,0.0001009971],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.002341857,0.01809285,0.0007331337,0.9540485,0.02220658,0.00000749055,0.00002650676,0.00005561524,0.002487412],"genre_scores_gemma":[0.05595449,0.01997668,0.0009060041,0.6715496,0.2463381,0.00003261504,0.00004218632,0.00005718247,0.005143214],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01856802,"threshold_uncertainty_score":0.01627851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03560306795914712,"score_gpt":0.2825121720517778,"score_spread":0.2469091040926306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}