{"id":"W2051173337","doi":"10.1073/pnas.1206530109","title":"Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death","year":2012,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":249,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Cancer Research UK","keywords":"Glycolysis; Mitochondrion; Cell biology; Reactive oxygen species; Hexokinase; Pentose phosphate pathway; Mitochondrial ROS; Programmed cell death; Biology; Apoptosis; Biochemistry; Chemistry; Metabolism","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002788889,0.00006172914,0.00009112991,0.00004631718,0.000065361,0.00000791692,0.0001410076,0.00006970638,0.000003235494],"category_scores_gemma":[0.0001068867,0.00004425391,0.00002853339,0.0001204714,0.0004216062,0.00002728269,0.00007897012,0.00003893241,7.591323e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003888503,"about_ca_system_score_gemma":0.00002033804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005837265,"about_ca_topic_score_gemma":6.40878e-8,"domain_scores_codex":[0.9993394,0.000003812434,0.0001476897,0.0001311637,0.0002804312,0.0000974903],"domain_scores_gemma":[0.9996458,0.00001629499,0.0001758273,0.000006601947,0.0001199838,0.00003551236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002261081,0.00002405782,0.007358046,0.00003635185,0.000008394133,1.308814e-10,0.00007202135,0.0001239889,0.9891307,0.00248416,0.0006082163,0.0001314193],"study_design_scores_gemma":[0.0003352074,0.00005080568,0.03275828,0.00002053068,0.00002342581,0.000003464505,0.0001076544,0.0003502856,0.9598576,0.002931442,0.003490436,0.00007082323],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965683,0.002217464,0.00002338389,0.0001917566,0.00007360084,0.00009903052,0.00001019436,0.000001594493,0.0008146762],"genre_scores_gemma":[0.998329,0.0003880094,0.0007577958,0.0001121806,0.0002732373,0.000002136873,4.184681e-7,0.000003049849,0.0001341895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02927309,"threshold_uncertainty_score":0.1804622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02200379347597609,"score_gpt":0.2764072429230444,"score_spread":0.2544034494470683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}