{"id":"W2051173965","doi":"10.1126/science.1243462","title":"Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA","year":2014,"lang":"en","type":"article","venue":"Science","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":874,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Partenariat Canadien Contre Le Cancer; Deutsche Forschungsgemeinschaft","keywords":"cccDNA; Hepatitis B virus; Lymphotoxin; Virology; Cytidine deaminase; Cytidine; Biology; Hepatitis B virus PRE beta; DNA; Virus; Hepatitis B virus DNA polymerase; Receptor; Enzyme; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002932906,0.0002812454,0.000182069,0.0001679226,0.0001511023,0.0001929282,0.0001103576,0.0003007124,0.00179327],"category_scores_gemma":[0.000249146,0.0001197604,0.000198646,0.00008372247,0.0002393149,0.0001935715,0.000179686,0.0002966193,0.0004106602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001418173,"about_ca_system_score_gemma":0.0001959899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001997116,"about_ca_topic_score_gemma":0.0003800602,"domain_scores_codex":[0.9997529,0.00007669831,0.00002007008,0.00005686372,0.00005491511,0.00003851701],"domain_scores_gemma":[0.9997898,0.00004611828,0.00004871763,0.00005665373,0.00003496115,0.00002383512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006398547,0.00001609468,0.0001314967,0.00003932121,0.000003617605,0.00003578483,0.00001068024,0.00001296459,0.9974989,0.00009865547,0.00001974105,0.00206872],"study_design_scores_gemma":[0.00001313096,0.0005029581,0.002108659,0.000006463109,0.000007224436,0.0005034308,0.0000124165,0.0001309395,0.9948483,0.00005328848,0.001811055,0.000002136427],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9567537,0.01227328,0.02267732,0.0001621197,0.00009599578,0.0001792138,0.0002526312,0.0002426169,0.007363068],"genre_scores_gemma":[0.9886303,0.001694462,0.004614401,0.00007423368,0.00001897625,0.00005385432,0.0002839742,0.00002231188,0.004607552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00179327,"threshold_uncertainty_score":0.005999088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02013978852024207,"score_gpt":0.2611237577242022,"score_spread":0.2409839692039601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}