{"id":"W2051217976","doi":"10.1540/jsmr.49.26","title":"Membrane depolarization-induced RhoA/Rho-associated kinase activation and sustained contraction of rat caudal arterial smooth muscle involves genistein-sensitive tyrosine phosphorylation","year":2013,"lang":"en","type":"article","venue":"Journal of Smooth Muscle Research","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Genistein; RHOA; Protein tyrosine phosphatase; Tyrosine phosphorylation; Rho-associated protein kinase; Tyrosine kinase; Myosin light-chain kinase; Phosphorylation; Myosin-light-chain phosphatase; Chemistry; Biology; Endocrinology; Cell biology; Internal medicine; Biochemistry; Signal transduction; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001146063,0.0001602679,0.0002691774,0.000278462,0.0002074856,0.0001044385,0.0001022715,0.000253959,0.00004727943],"category_scores_gemma":[0.0005736474,0.0001518589,0.00009870824,0.0002957735,0.0001568187,0.00008510629,0.00005309872,0.0002905153,0.000001812456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001266947,"about_ca_system_score_gemma":0.000329661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001619971,"about_ca_topic_score_gemma":0.00002892332,"domain_scores_codex":[0.9979463,0.0003631421,0.0005734453,0.0002362487,0.0005834854,0.0002974229],"domain_scores_gemma":[0.9969577,0.0001084511,0.0005538922,0.0001743347,0.00204072,0.0001649315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003700749,0.000135494,0.0001135525,0.00003962555,0.00004796344,0.000007670226,0.000163805,0.00009180474,0.9894297,0.00009932635,0.0001492432,0.009351708],"study_design_scores_gemma":[0.002308017,0.0006001503,0.03850617,0.0001201807,0.00002504352,0.000007868385,0.0005918304,0.0008922802,0.9558451,0.0002748146,0.000662964,0.000165563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963105,0.0002006042,0.002273199,0.0004909291,0.00009733412,0.0004972774,0.000004653646,0.000007207749,0.0001182339],"genre_scores_gemma":[0.9989455,0.0001231747,0.0002425708,0.00004212564,0.0002825846,0.00001059559,0.00007749798,0.00002777266,0.0002481889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03839261,"threshold_uncertainty_score":0.6192626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02434079845515955,"score_gpt":0.2864421295798819,"score_spread":0.2621013311247223,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}