{"id":"W2051220021","doi":"10.1016/j.canlet.2008.09.021","title":"Enhancement of cytotoxicity of natural product drugs against multidrug resistant variant cell lines of human head and neck squamous cell carcinoma and breast carcinoma by tesmilifene","year":2008,"lang":"en","type":"article","venue":"Cancer Letters","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"London Health Sciences Centre; Lawson Health Research Institute; Western University","funders":"London Health Sciences Centre","keywords":"Docetaxel; Doxorubicin; Cancer research; Head and neck squamous-cell carcinoma; Propidium iodide; Cytotoxicity; Cell culture; Paclitaxel; Medicine; Biology; Pharmacology; Cancer; Apoptosis; Internal medicine; Chemotherapy; Programmed cell death; Head and neck cancer; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001937666,0.0002181289,0.000243679,0.0001891378,0.0001128421,0.0001598208,0.0001767649,0.0001959916,0.001665583],"category_scores_gemma":[0.0002076889,0.0001002168,0.0002532385,0.0001255222,0.0001466431,0.0001776287,0.0001554536,0.0002957557,0.0002650849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001211818,"about_ca_system_score_gemma":0.0001533828,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004349536,"about_ca_topic_score_gemma":0.0005741043,"domain_scores_codex":[0.999886,0.00004551522,0.00001365902,0.00001099318,0.00001735041,0.00002635749],"domain_scores_gemma":[0.9998696,0.00005365974,0.00001433033,0.00002029847,0.00002473416,0.00001731618],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000840922,0.00009264347,0.0005347956,0.00004074441,0.000008250609,0.00006820835,0.00003742695,0.00008674072,0.9948859,0.00007898118,0.00004765608,0.003277686],"study_design_scores_gemma":[0.00003211272,0.001009159,0.002269385,0.000003280512,0.00001308096,0.0001527264,0.00002385926,0.0002636554,0.9955629,0.00002198754,0.0006449681,0.000002898318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970902,0.001122587,0.0004988908,0.00005304421,0.00001641584,0.00001495062,0.0001529484,0.00002212802,0.001028734],"genre_scores_gemma":[0.9977919,0.0005202679,0.0003324942,0.00001873221,0.000007005744,0.00001262407,0.0003477773,0.000004738046,0.0009645047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001665583,"threshold_uncertainty_score":0.005571961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00723464199172592,"score_gpt":0.2200037197417903,"score_spread":0.2127690777500644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}