{"id":"W2051220021","doi":"10.1016/j.canlet.2008.09.021","title":"Enhancement of cytotoxicity of natural product drugs against multidrug resistant variant cell lines of human head and neck squamous cell carcinoma and breast carcinoma by tesmilifene","year":2008,"lang":"en","type":"article","venue":"Cancer Letters","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"London Health Sciences Centre; Lawson Health Research Institute; Western University","funders":"London Health Sciences Centre","keywords":"Docetaxel; Doxorubicin; Cancer research; Head and neck squamous-cell carcinoma; Propidium iodide; Cytotoxicity; Cell culture; Paclitaxel; Medicine; Biology; Pharmacology; Cancer; Apoptosis; Internal medicine; Chemotherapy; Programmed cell death; Head and neck cancer; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000689481,0.0002214157,0.0003493615,0.00003956029,0.00006525427,0.000003736981,0.0001519559,0.00006641966,0.000003140538],"category_scores_gemma":[0.00001039368,0.0002118191,0.00007088346,0.0000559839,0.0004473155,0.000006250928,0.000112747,0.00009614723,9.020281e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000268534,"about_ca_system_score_gemma":0.00005929988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005148562,"about_ca_topic_score_gemma":0.00003391235,"domain_scores_codex":[0.9987509,0.00004490502,0.0003865262,0.0004555143,0.0001321444,0.0002299642],"domain_scores_gemma":[0.9991833,0.00001329817,0.0002873011,0.000317427,0.0001207647,0.0000779151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002409874,0.0001350791,0.03323309,0.0004073118,0.00002042793,0.000003465623,0.0005334741,0.000009750454,0.9641497,5.325708e-7,0.001198445,0.00006770631],"study_design_scores_gemma":[0.001445363,0.0001676034,0.04014349,0.00002734199,0.00002592937,0.000004315497,0.00008003523,0.00001833316,0.9577968,0.000001101086,0.00008864575,0.0002010638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925807,0.006520493,0.00001708065,0.0001627631,0.00006329078,0.0002850375,0.0003067249,0.000002811867,0.00006115714],"genre_scores_gemma":[0.998803,0.0002681063,0.0003509057,0.0002264157,0.0001180593,0.00001907889,0.0001055698,0.00002072638,0.00008817604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0069104,"threshold_uncertainty_score":0.8637731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00723464199172592,"score_gpt":0.2200037197417903,"score_spread":0.2127690777500644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}