{"id":"W2051239639","doi":"10.1371/journal.pone.0085401","title":"Cysteine Peptidases as Schistosomiasis Vaccines with Inbuilt Adjuvanticity","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Parasites and Host Interactions","field":"Immunology and Microbiology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Science and Technology Development Fund","keywords":"Schistosoma mansoni; Fasciola hepatica; Adjuvant; Praziquantel; Schistosoma; Fasciola; Schistosomiasis; Biology; Cathepsin L; Cysteine protease; Tropical disease; Cathepsin; Chemistry; Microbiology; Immunology; Proteases; Biochemistry; Medicine; Helminths; Enzyme; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.00005791935,0.0001404136,0.0002847044,0.00008615625,0.000184524,0.00001480827,0.000140333,0.00009746136,0.001323524],"category_scores_gemma":[0.0001613263,0.0001104176,0.00004585346,0.00009152519,0.00006804854,0.0001027939,0.000040525,0.000211934,0.003000624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000193785,"about_ca_system_score_gemma":0.00002190597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003767415,"about_ca_topic_score_gemma":0.000205744,"domain_scores_codex":[0.9992766,0.00007285646,0.0001624442,0.0002186212,0.00003812258,0.0002313752],"domain_scores_gemma":[0.999351,0.0001417648,0.00008577278,0.0002887675,0.0001058415,0.00002684827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004261014,0.00204062,0.07045219,0.00005134025,0.0008852292,0.000004668088,0.0001996863,0.000004065015,0.920666,0.00165773,0.0024146,0.001197782],"study_design_scores_gemma":[0.003839338,0.002358461,0.06012836,0.0006641477,0.0008433451,0.0001785489,0.0001669087,0.0000674539,0.8940895,0.0002724177,0.03675177,0.0006397066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861056,0.0004446082,0.00009380023,0.0006557481,0.00007923509,0.000140524,0.00001773993,0.000115517,0.01234719],"genre_scores_gemma":[0.9864209,0.00003376406,0.0004616877,0.000370381,0.0000673537,0.00002600266,0.00005757174,0.0000162229,0.01254617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03433717,"threshold_uncertainty_score":0.9995894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02264151361770851,"score_gpt":0.2347382712408926,"score_spread":0.212096757623184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}