{"id":"W2051239639","doi":"10.1371/journal.pone.0085401","title":"Cysteine Peptidases as Schistosomiasis Vaccines with Inbuilt Adjuvanticity","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Parasites and Host Interactions","field":"Immunology and Microbiology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Science and Technology Development Fund","keywords":"Schistosoma mansoni; Fasciola hepatica; Adjuvant; Praziquantel; Schistosoma; Fasciola; Schistosomiasis; Biology; Cathepsin L; Cysteine protease; Tropical disease; Cathepsin; Chemistry; Microbiology; Immunology; Proteases; Biochemistry; Medicine; Helminths; Enzyme; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001572547,0.0004121794,0.0002658387,0.000201855,0.00005267548,0.0001761017,0.0001544011,0.000332519,0.0006295],"category_scores_gemma":[0.0000953577,0.0001091475,0.0002046023,0.0001072215,0.0001591917,0.000178108,0.0001774953,0.0004915602,0.0001625812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001244049,"about_ca_system_score_gemma":0.000109026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001219627,"about_ca_topic_score_gemma":0.0002114402,"domain_scores_codex":[0.9999309,0.00001748675,0.00000520075,0.000008906057,0.00001863368,0.00001891449],"domain_scores_gemma":[0.9999502,0.00000778411,0.00001501354,0.000004501069,0.000007758112,0.00001474448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001513924,0.00008873695,0.00006613308,0.0001331152,0.000006869309,0.00003577171,0.00000941046,0.0002351669,0.9947608,0.0001139578,0.0000334654,0.004365131],"study_design_scores_gemma":[0.0001204208,0.003614618,0.0008132499,0.00002477854,0.00005498698,0.0002726835,0.00001176033,0.0005701634,0.9876612,0.0001030689,0.006747479,0.000005509734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714292,0.01432285,0.01100711,0.0003087095,0.000220007,0.0002474317,0.0002164883,0.0001599338,0.002088256],"genre_scores_gemma":[0.9853317,0.006672086,0.005765152,0.0001063751,0.00006053882,0.00006709919,0.0002215702,0.00001102961,0.001764596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006295,"threshold_uncertainty_score":0.002105951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02264151361770851,"score_gpt":0.2347382712408926,"score_spread":0.212096757623184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}