{"id":"W2051248464","doi":"10.1016/j.bbrc.2012.11.087","title":"Epigallocatechin-3-gallate up-regulates tumor suppressor gene expression via a reactive oxygen species-dependent down-regulation of UHRF1","year":2012,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"Tea Polyphenols and Effects","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":false,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Ligue Contre le Cancer; DSM Nutritional Products; Fondation pour la Recherche Médicale; Agence Nationale de la Recherche; Association pour la Recherche sur le Cancer","keywords":"Promoter; Gene silencing; DNA methylation; DNMT1; Biology; Cell biology; Tumor suppressor gene; Jurkat cells; Suppressor; Reactive oxygen species; Apoptosis; Regulation of gene expression; Gene; Molecular biology; Gene expression; Carcinogenesis; Biochemistry; Genetics; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001210175,0.0005314747,0.0002943815,0.0004301748,0.0002040492,0.0002570089,0.00021145,0.0001995234,0.001078604],"category_scores_gemma":[0.0001372945,0.000232153,0.0005680938,0.0002102564,0.0002678531,0.0002038707,0.0002670089,0.0005251151,0.00037271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003601178,"about_ca_system_score_gemma":0.0001926387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001011046,"about_ca_topic_score_gemma":0.00141048,"domain_scores_codex":[0.9998579,0.00001863023,0.00001070979,0.00002924401,0.00002697453,0.00005648452],"domain_scores_gemma":[0.9999098,0.00001306178,0.00002666022,0.00001400713,0.0000123396,0.00002410777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002677764,0.00001989039,0.0001242487,0.00001779988,0.000008903391,0.0000389112,0.00000851416,0.00002000071,0.998755,0.00004502801,0.00005030414,0.0006435949],"study_design_scores_gemma":[0.0000232393,0.0001236142,0.009312645,0.000002755439,0.00003137513,0.0001097407,0.00001920001,0.000303308,0.9890847,0.00004883848,0.0009358973,0.000004756324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935157,0.002102094,0.002340351,0.0002274869,0.00007032192,0.00001580213,0.0003916596,0.0002035525,0.001132973],"genre_scores_gemma":[0.9963719,0.0006407106,0.0006620355,0.00007767339,0.00001209836,0.00001882891,0.0004445568,0.00003216053,0.001740084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001078604,"threshold_uncertainty_score":0.003608286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06473399839521271,"score_gpt":0.3489763505635511,"score_spread":0.2842423521683384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}