{"id":"W2051249711","doi":"10.1038/ni.1843","title":"HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species","year":2010,"lang":"en","type":"article","venue":"Nature Immunology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":228,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute","keywords":"breakpoint cluster region; Reactive oxygen species; Cell biology; B-cell receptor; Protein tyrosine phosphatase; Syk; Signal transduction; Chemistry; Protein kinase B; Biology; Receptor; Biochemistry; Tyrosine kinase; B cell; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001458139,0.000132156,0.0001717741,0.0001114998,0.00005586496,0.000005604993,0.0001159275,0.0007407392,0.0001585156],"category_scores_gemma":[0.00008208816,0.0001242737,0.00008429528,0.00009499882,0.0001242146,0.00001073393,0.00005076343,0.0003037902,0.000002980968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001386696,"about_ca_system_score_gemma":0.00004431052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001483732,"about_ca_topic_score_gemma":0.00004974548,"domain_scores_codex":[0.9991254,0.000063988,0.0002837938,0.0002501805,0.0001444785,0.0001321239],"domain_scores_gemma":[0.9990534,0.00001633447,0.000263892,0.0002785487,0.0003659647,0.0000219237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000195447,0.00007040828,0.0002800551,0.000006756863,0.00009071616,2.108974e-7,0.00006605448,0.0003205846,0.9927141,0.001681636,0.0003019653,0.004272082],"study_design_scores_gemma":[0.0004815222,0.0002378219,0.02912008,0.000004036231,0.00001753301,0.00001416443,0.00005277534,0.001595146,0.9626709,0.0003252749,0.005370221,0.0001105899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941617,0.0004539853,0.003008348,0.0001626308,0.001291118,0.0001564364,0.00002374581,0.00001158692,0.0007304598],"genre_scores_gemma":[0.9972383,0.00005145277,0.0005313987,0.00003268964,0.0005902214,0.00000689388,0.0007296822,0.00001452012,0.0008048511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03004325,"threshold_uncertainty_score":0.5713259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007781061592397893,"score_gpt":0.2259251892597461,"score_spread":0.2181441276673482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}