{"id":"W2051253171","doi":"10.1038/nm.3270","title":"Endogenous factor VIII synthesis from the intron 22–inverted F8 locus may modulate the immunogenicity of replacement therapy for hemophilia A","year":2013,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"U.S. National Library of Medicine; National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute; Baxter Healthcare Corporation; National Cancer Institute; National Institutes of Health; Bayer HealthCare; University of California, San Francisco; University of Southern California","keywords":"Immunogenicity; Locus (genetics); Intron; Endogeny; Immunology; Medicine; Genetic enhancement; Genetics; Biology; Virology; Gene; Antibody; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006248103,0.0003509031,0.0007121083,0.00009713641,0.0002476424,0.00001605494,0.0004747267,0.000368219,0.001926339],"category_scores_gemma":[0.0009881185,0.0001385964,0.000254495,0.0003315248,0.0004548153,0.00005438281,0.00007655164,0.0008171622,0.00003563129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001532994,"about_ca_system_score_gemma":0.0001388651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001400045,"about_ca_topic_score_gemma":0.00002614662,"domain_scores_codex":[0.9974155,0.0001932618,0.0005236713,0.0004467411,0.0009171526,0.0005036226],"domain_scores_gemma":[0.9962776,0.001782124,0.000194988,0.001162189,0.0004324557,0.0001506788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005267417,0.000691226,0.01077472,0.0001364257,0.002746636,0.00002761741,0.002912612,0.000002605295,0.8294047,0.0001419487,0.02645378,0.1214403],"study_design_scores_gemma":[0.02201699,0.005233359,0.06826182,0.0008392434,0.001062491,0.00009351659,0.001516859,0.00174995,0.8574682,0.001766491,0.03948472,0.0005063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9251941,0.01528154,0.0000497887,0.05425722,0.0003877214,0.003981281,0.00009060279,0.00005324178,0.0007044474],"genre_scores_gemma":[0.993618,0.001379212,0.0001351268,0.002403511,0.0008608069,0.0004019395,0.00009450917,0.00004875349,0.001058155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.120934,"threshold_uncertainty_score":0.9989861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03300181014586383,"score_gpt":0.2992525152013846,"score_spread":0.2662507050555207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}