{"id":"W2051255001","doi":"10.1038/nature04524","title":"Regulation of cancer cell migration and bone metastasis by RANKL","year":2006,"lang":"en","type":"article","venue":"Nature","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":795,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Ontario Tech University; McGill University; University Health Network; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Arthritis Network; European Commission; Institute of Musculoskeletal Health and Arthritis; National Cancer Institute; Oesterreichische Nationalbank; Canadian Institutes of Health Research","keywords":"RANKL; Cancer research; Osteoprotegerin; Metastasis; Cancer cell; Cancer; Bone metastasis; Breast cancer; Melanoma; Medicine; Chemokine receptor; Biology; Receptor; Chemokine; Immunology; Internal medicine; Activator (genetics)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001810763,0.0004279767,0.0002502321,0.0004916998,0.0003582033,0.0009060563,0.0003250448,0.000329298,0.001786375],"category_scores_gemma":[0.0001782949,0.000302784,0.0002542829,0.0002442549,0.0004638824,0.0003079597,0.0003238074,0.0006525338,0.0007854705],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008071413,"about_ca_system_score_gemma":0.0004012886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001780095,"about_ca_topic_score_gemma":0.003218546,"domain_scores_codex":[0.9997482,0.00004686538,0.00001329365,0.00002061834,0.00007389149,0.00009704964],"domain_scores_gemma":[0.9998792,0.0000179714,0.00003745886,0.00001258012,0.00001960369,0.00003317399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004686295,0.00003901242,0.000730669,0.0001188534,0.00001203045,0.0003375608,0.00005531157,0.0003295947,0.9823366,0.003306612,0.0009150385,0.01135001],"study_design_scores_gemma":[0.00009388359,0.0004108691,0.02297965,0.00002580344,0.0000359717,0.00114104,0.0002100032,0.0026035,0.9423254,0.00166325,0.02848216,0.0000284543],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9193438,0.0524962,0.008485622,0.003124131,0.0002484352,0.00005166344,0.0009150301,0.0004898682,0.01484519],"genre_scores_gemma":[0.983124,0.006233372,0.001733584,0.0001349952,0.00005302756,0.00002835677,0.0003300674,0.00002947755,0.008333251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001786375,"threshold_uncertainty_score":0.005976021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002052744175920116,"score_gpt":0.2199729129185765,"score_spread":0.2179201687426564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}