{"id":"W2051284735","doi":"10.1021/ol401275f","title":"Total Synthesis of the Cytotoxic Enehydrazide Natural Products Hydrazidomycins A and B by a Carbazate Addition/Peterson Olefination Approach","year":2013,"lang":"en","type":"article","venue":"Organic Letters","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Regioselectivity; Silylation; Stereochemistry; Ring (chemistry); Epoxide; Hydrazide; Total synthesis; Silyl ether; Combinatorial chemistry; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001940838,0.0003083442,0.0003226851,0.00003609605,0.0001275992,0.00006107305,0.0003792875,0.0001423709,0.0007682638],"category_scores_gemma":[0.0008546754,0.0002444282,0.00009321997,0.0002872598,0.0002563327,0.0001833076,0.0001644152,0.0003196794,0.00001595519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001892936,"about_ca_system_score_gemma":0.0000603773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006808706,"about_ca_topic_score_gemma":0.000001055548,"domain_scores_codex":[0.9982389,0.00009519243,0.0003641695,0.0005555412,0.0003885734,0.0003576762],"domain_scores_gemma":[0.9986025,0.000274639,0.0002744132,0.0007052143,0.00006671661,0.00007653006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006825236,0.00006269281,0.0001532542,0.000224855,0.00006392723,9.39572e-7,0.0003263882,9.005527e-7,0.9936618,0.000004108245,0.004131415,0.001362868],"study_design_scores_gemma":[0.0003381947,0.000004816799,0.0006920524,0.00008168945,0.00008243509,0.0001347723,0.0001928325,0.0002972329,0.9977335,0.00001465985,0.0001523757,0.0002753893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938341,0.0001356906,0.00009019896,0.004706537,0.0001179308,0.0002254292,0.00005498984,0.00008383922,0.0007513255],"genre_scores_gemma":[0.9971641,0.000009020699,0.001753706,0.0002941601,0.0001625647,0.00008756777,0.00002714624,0.00006639833,0.0004353232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004412377,"threshold_uncertainty_score":0.9967494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004476940363130387,"score_gpt":0.1830359284497281,"score_spread":0.1785589880865977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}