{"id":"W2051291394","doi":"10.1038/mt.2009.90","title":"Heat Shock Protein 27 as a New Therapeutic Target for Radiation Sensitization of Head and Neck Squamous Cell Carcinoma","year":2009,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital","funders":"","keywords":"Radioresistance; Cancer research; Head and neck squamous-cell carcinoma; Medicine; Hsp27; Protein kinase B; Apoptosis; Radiation therapy; Heat shock protein; Internal medicine; Head and neck cancer; Chemistry; Hsp70","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001532914,0.0001902366,0.0001891829,0.00007649026,0.00006535929,0.00002901978,0.0001235073,0.0001892245,0.00001802475],"category_scores_gemma":[0.00006150607,0.0001864415,0.00009770712,0.0001251053,0.00003449596,0.000006615768,0.00002074087,0.00007760802,0.000003323316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002233871,"about_ca_system_score_gemma":0.0002361465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008340672,"about_ca_topic_score_gemma":0.000003955968,"domain_scores_codex":[0.9987867,0.0001249406,0.0002186669,0.0003731404,0.0001961309,0.0003003493],"domain_scores_gemma":[0.9993261,0.00001090873,0.00003719662,0.0003533902,0.0001181466,0.0001542374],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005217196,0.0001002007,0.000243961,0.00002624981,0.00001584459,0.000003776171,0.00007615059,0.0001271063,0.9815668,0.0001109337,0.0001506991,0.01705654],"study_design_scores_gemma":[0.002667565,0.003504437,0.0007094472,0.000008018288,0.000006200364,0.000008993707,0.000008957216,0.000633537,0.9828891,0.00113513,0.008238222,0.0001903591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.96635,0.007054737,0.0231511,0.001463316,0.00002644298,0.001659499,0.00000984103,0.00001128015,0.0002737779],"genre_scores_gemma":[0.9960119,0.0001279084,0.002162308,0.0007394846,0.00009796482,0.0000437023,0.000135651,0.00003827619,0.0006428017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02966189,"threshold_uncertainty_score":0.7602862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01214249140159167,"score_gpt":0.2753864018674305,"score_spread":0.2632439104658388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}