{"id":"W2051340061","doi":"10.1002/pro.267","title":"Design of high‐affinity S100‐target hybrid proteins","year":2009,"lang":"en","type":"article","venue":"Protein Science","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Annexin A2; Chemistry; Cleavage (geology); Peptide sequence; Linker; Target protein; Biochemistry; Peptide; Biophysics; Annexin; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001860495,0.000487361,0.0004420465,0.0001986064,0.0001818058,0.000493746,0.0005871645,0.0006583937,0.001718132],"category_scores_gemma":[0.0001736022,0.0003405873,0.0003950299,0.0002721733,0.0001921326,0.0002488578,0.0003409884,0.0007631388,0.00110484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008260648,"about_ca_system_score_gemma":0.0001673842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004698815,"about_ca_topic_score_gemma":0.0008967304,"domain_scores_codex":[0.9997825,0.00003308857,0.00001470063,0.00004911384,0.00007197131,0.00004870041],"domain_scores_gemma":[0.9998834,0.00002073131,0.00002380584,0.000007567374,0.00002311316,0.0000412958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007616408,0.00004945855,0.00008566079,0.00003881457,0.00001415145,0.00005465298,0.00001667284,0.0003855712,0.997982,0.0001169504,0.00007975924,0.001100046],"study_design_scores_gemma":[0.00005832836,0.000298423,0.0008802626,0.000005423862,0.00002667581,0.0002082524,0.00003907453,0.003690988,0.9888023,0.00004933171,0.005925501,0.00001547067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820274,0.0008981417,0.01424868,0.0001660117,0.00005799405,0.0001925646,0.0003353936,0.0001905451,0.0018834],"genre_scores_gemma":[0.9723976,0.0008402636,0.01884386,0.0002371881,0.00001960156,0.0002622295,0.001040966,0.00007322142,0.006285033],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001718132,"threshold_uncertainty_score":0.005993545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01541150563774883,"score_gpt":0.2505880700482851,"score_spread":0.2351765644105362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}