{"id":"W2051340061","doi":"10.1002/pro.267","title":"Design of high‐affinity S100‐target hybrid proteins","year":2009,"lang":"en","type":"article","venue":"Protein Science","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Annexin A2; Chemistry; Cleavage (geology); Peptide sequence; Linker; Target protein; Biochemistry; Peptide; Biophysics; Annexin; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008583818,0.000162741,0.0001671348,0.0000853268,0.0001893779,0.00004356902,0.0006606714,0.00006207223,0.00003307966],"category_scores_gemma":[0.0003359754,0.0001418098,0.00005631937,0.0003965169,0.0004250928,0.00001908209,0.0001220815,0.00009669432,0.00001207695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001649138,"about_ca_system_score_gemma":0.0003536102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000272359,"about_ca_topic_score_gemma":0.000001351627,"domain_scores_codex":[0.9983965,0.00005876307,0.0002432141,0.0005160352,0.0003816023,0.0004039559],"domain_scores_gemma":[0.9989679,0.000004909205,0.0001404204,0.0005411762,0.0002180285,0.0001274978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005530459,0.0001126319,0.00003713949,0.000007691643,0.000003472715,0.000003021197,0.00002020343,0.000215221,0.9930719,0.0009461523,0.00005615275,0.005471077],"study_design_scores_gemma":[0.0002663313,0.0009918397,0.001063537,0.00002485864,0.000002649532,0.000008715746,0.00001033656,0.0002149545,0.9926813,0.003580925,0.0009647883,0.0001897997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8844786,0.0002684995,0.1127113,0.0002878271,0.00006096945,0.001174507,0.000009191812,0.0000280465,0.0009810571],"genre_scores_gemma":[0.9462376,0.00001064525,0.05309552,0.0001661857,0.00009309476,0.00006155372,0.000005776689,0.000009016219,0.0003206636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0617589,"threshold_uncertainty_score":0.5782837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01541150563774883,"score_gpt":0.2505880700482851,"score_spread":0.2351765644105362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}