{"id":"W2051380923","doi":"10.1186/1471-2474-14-344","title":"Cathepsin K inhibitors increase distal femoral bone mineral density in rapidly growing rabbits","year":2013,"lang":"en","type":"article","venue":"BMC Musculoskeletal Disorders","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Annidis (Canada)","funders":"","keywords":"Cathepsin K; Bone resorption; In vivo; Pharmacology; Bone mineral; Potency; Medicine; Resorption; Osteoporosis; Internal medicine; Endocrinology; Bisphosphonate; In vitro; Chemistry; Osteoclast; Biochemistry; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005255553,0.0006605929,0.0007809555,0.0008417058,0.0001737672,0.000383785,0.0004007738,0.0005098104,0.001691752],"category_scores_gemma":[0.0005000631,0.0003494507,0.0006053068,0.000334757,0.0005047219,0.0003260675,0.0002584225,0.001061223,0.0008231362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004198558,"about_ca_system_score_gemma":0.0004279226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001423261,"about_ca_topic_score_gemma":0.002760016,"domain_scores_codex":[0.9995083,0.00006285233,0.00006858579,0.00009973713,0.0001630587,0.00009741892],"domain_scores_gemma":[0.9991737,0.0001080133,0.0003952149,0.00008281204,0.00008508568,0.0001551971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002357454,0.0006387373,0.001156871,0.0001002652,0.00002771669,0.0001990946,0.00006043843,0.00009306287,0.9905606,0.00006762337,0.000150178,0.004587953],"study_design_scores_gemma":[0.0006135245,0.02765169,0.01648288,0.00003640249,0.0001523154,0.001518611,0.0002145523,0.0009571558,0.9479243,0.00008466343,0.004338301,0.00002561247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926507,0.003291621,0.001573936,0.000183234,0.00005801543,0.00009460815,0.0004499725,0.0001521315,0.001545939],"genre_scores_gemma":[0.9856169,0.003155905,0.002887997,0.0001656008,0.00003796805,0.0001476799,0.001136047,0.00004328753,0.006808536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001691752,"threshold_uncertainty_score":0.005659521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005585076997363242,"score_gpt":0.2249973815781007,"score_spread":0.2194123045807374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}