{"id":"W2051386359","doi":"10.1016/j.febslet.2006.10.035","title":"Atomic determinants of state‐dependent block of sodium channels by charged local anesthetics and benzocaine","year":2006,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Benzocaine; Chemistry; Cationic polymerization; Ammonium; Biophysics; Sodium; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001267977,0.0001173756,0.0001784999,0.0001561093,0.0003915907,0.0003442854,0.0002212746,0.000209132,0.001574272],"category_scores_gemma":[0.0004161466,0.0001676478,0.0001467584,0.0000787973,0.0003821367,0.0002125655,0.0002435466,0.0002924159,0.000148807],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004583334,"about_ca_system_score_gemma":0.000242657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002040251,"about_ca_topic_score_gemma":0.002412658,"domain_scores_codex":[0.9999412,0.000007110535,0.00000284402,0.00000802441,0.00001968542,0.0000211597],"domain_scores_gemma":[0.99979,0.00006001288,0.0000550664,0.0000127643,0.00002973704,0.00005230674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008992742,0.0001280677,0.01463303,0.00005451121,0.00004914211,0.0003663322,0.0001402743,0.01569988,0.9576045,0.006457865,0.0003562178,0.003610909],"study_design_scores_gemma":[0.0003891972,0.001252157,0.1935933,0.00002117334,0.0002070164,0.0006462336,0.000378381,0.3071962,0.4884808,0.005615595,0.002113737,0.0001063488],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998442,0.00006538967,0.0005923668,0.00004501278,0.000004536324,0.000003948737,0.0000203222,0.00002034009,0.000806044],"genre_scores_gemma":[0.999823,0.00002359709,0.00008064153,0.000004415116,0.000001403824,0.000001864421,0.00001820165,0.000003271375,0.00004366237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002040251,"threshold_uncertainty_score":0.005266488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004845537729326005,"score_gpt":0.2038816417103514,"score_spread":0.1990361039810254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}