{"id":"W2051426690","doi":"10.1097/ccm.0b013e31828e9b03","title":"A Randomized, Double-Blind, Placebo-Controlled, Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Soluble Thrombomodulin, ART-123, in Patients With Sepsis and Suspected Disseminated Intravascular Coagulation*","year":2013,"lang":"en","type":"article","venue":"Critical Care Medicine","topic":"Sepsis Diagnosis and Treatment","field":"Medicine","cited_by":322,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; McMaster University; St. Joseph's Hospital; Royal Alexandra Hospital","funders":"","keywords":"Medicine; Disseminated intravascular coagulation; Placebo; Clinical endpoint; Sepsis; Internal medicine; Randomized controlled trial; Hemostasis; Thrombomodulin; Surgery; Gastroenterology; Pathology; Platelet; Thrombin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001010735,0.0003387002,0.001792222,0.0002170854,0.0001629651,0.00003030448,0.00008436366,0.00007389863,0.0003011819],"category_scores_gemma":[0.00154218,0.0001685817,0.00008945206,0.0003561312,0.0005842056,0.0000772764,0.00006541399,0.0002225127,0.000006819404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009680504,"about_ca_system_score_gemma":0.00003904433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000535824,"about_ca_topic_score_gemma":0.0001769178,"domain_scores_codex":[0.9972001,0.0004020927,0.0008702364,0.0005142687,0.0006680592,0.0003452714],"domain_scores_gemma":[0.9965521,0.001712111,0.00008342633,0.0004538978,0.0008696879,0.0003288269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8134515,0.01072871,0.1569615,0.0002962718,0.001338483,0.00005343183,0.01248876,0.0000116795,0.0001062073,0.0005369225,0.000592809,0.003433741],"study_design_scores_gemma":[0.7897974,0.007063508,0.1946428,0.0006006268,0.002558884,0.000004523413,0.004814627,0.0002057704,0.00007547803,0.0000698619,0.00001171148,0.0001548418],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822127,0.001029617,0.00003665815,0.004921414,0.0001193396,0.01145182,0.000003470772,0.00002717882,0.0001978299],"genre_scores_gemma":[0.9987461,0.00004712255,0.00004982551,0.0002114868,0.00004570791,0.0006962131,0.0001317012,0.00003173298,0.00004008527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03768125,"threshold_uncertainty_score":0.6874561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04210995641577293,"score_gpt":0.3758274784333532,"score_spread":0.3337175220175803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}