{"id":"W2051426690","doi":"10.1097/ccm.0b013e31828e9b03","title":"A Randomized, Double-Blind, Placebo-Controlled, Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Soluble Thrombomodulin, ART-123, in Patients With Sepsis and Suspected Disseminated Intravascular Coagulation*","year":2013,"lang":"en","type":"article","venue":"Critical Care Medicine","topic":"Sepsis Diagnosis and Treatment","field":"Medicine","cited_by":322,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; McMaster University; St. Joseph's Hospital; Royal Alexandra Hospital","funders":"","keywords":"Medicine; Disseminated intravascular coagulation; Placebo; Clinical endpoint; Sepsis; Internal medicine; Randomized controlled trial; Hemostasis; Thrombomodulin; Surgery; Gastroenterology; Pathology; Platelet; Thrombin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003162118,0.00216988,0.003537229,0.0005561445,0.0004880122,0.0009803687,0.0008744602,0.002295195,0.005791424],"category_scores_gemma":[0.003488607,0.000837619,0.001269908,0.0004953697,0.001518137,0.0009460043,0.0003589545,0.002201631,0.0008692991],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006611909,"about_ca_system_score_gemma":0.001770623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005530619,"about_ca_topic_score_gemma":0.001025343,"domain_scores_codex":[0.9986285,0.0008648794,0.00008704967,0.0001883255,0.0001007913,0.0001304913],"domain_scores_gemma":[0.9980984,0.0005974212,0.0004487249,0.0001495089,0.0001619451,0.0005440622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9816921,0.009388709,0.0005009004,0.0003096536,0.0002805162,0.00002313308,0.00002680517,0.0001084288,0.001811344,0.00005116054,0.0003306562,0.005476547],"study_design_scores_gemma":[0.9606,0.03835226,0.0005348621,0.000008737752,0.00008732874,0.00001042611,0.000004196484,0.00009784377,0.0001177554,0.00002227706,0.0001599462,0.000004418426],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758597,0.003052002,0.00146006,0.0007413558,0.0006714687,0.01548941,0.001097386,0.0001251043,0.001503576],"genre_scores_gemma":[0.9626918,0.002617234,0.005126002,0.00216658,0.000893462,0.02267461,0.00146541,0.00003038717,0.002334465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005791424,"threshold_uncertainty_score":0.01937425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04210995641577293,"score_gpt":0.3758274784333532,"score_spread":0.3337175220175803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}