{"id":"W2051429365","doi":"10.1016/s1359-6446(05)03566-x","title":"Using microarray gene signatures to elucidate mechanisms of antibiotic action and resistance","year":2005,"lang":"en","type":"review","venue":"Drug Discovery Today","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":125,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Genome Prairie; Canada Research Chairs; Genome British Columbia; Cystic Fibrosis Foundation","keywords":"Antibiotics; Biology; Computational biology; Gene; Microarray; Microarray analysis techniques; Gene expression; DNA microarray; Antibiotic resistance; Drug discovery; Mechanism (biology); Genetics; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001348533,0.001204018,0.00222942,0.002110297,0.0001966402,0.001289941,0.001178268,0.001279491,0.001254187],"category_scores_gemma":[0.0009306782,0.0004232751,0.0004960404,0.002286136,0.0009729879,0.001326053,0.0004851757,0.001612327,0.001375597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007173284,"about_ca_system_score_gemma":0.000686611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008706785,"about_ca_topic_score_gemma":0.00183744,"domain_scores_codex":[0.9996722,0.00004305082,0.00002406247,0.00007985776,0.0001559231,0.00002499721],"domain_scores_gemma":[0.9993899,0.0003335308,0.00006538949,0.00002892532,0.0001463777,0.00003581316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001103165,0.00007845752,0.0008436802,0.004926766,0.00008363534,0.0001927093,0.00005171083,0.0004590644,0.04308947,0.003532121,0.009345775,0.9372863],"study_design_scores_gemma":[0.00007953883,0.000362382,0.009133081,0.001837607,0.0003028887,0.004150836,0.0002337943,0.00119521,0.03703734,0.01041729,0.9351022,0.0001479468],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001014559,0.9905008,0.00548382,0.0005512441,0.0003822242,0.00001907934,0.00008513044,0.00004997373,0.001913038],"genre_scores_gemma":[0.003156275,0.9882912,0.00532989,0.0004973458,0.000300211,0.00003072182,0.0001437579,0.000005859103,0.002244661],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00222942,"threshold_uncertainty_score":0.007131875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0312711334107072,"score_gpt":0.3124807413274064,"score_spread":0.2812096079166992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}