{"id":"W2051433490","doi":"10.1084/jem.192.9.1365","title":"The Notch Ligand Jagged-1 Represents a Novel Growth Factor of Human Hematopoietic Stem Cells","year":2000,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":429,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Medical Research Council; Medical Research Council Canada; Amgen","keywords":"Stem cell; Cell biology; Biology; Stem cell factor; Haematopoiesis; Notch signaling pathway; Induced pluripotent stem cell; Embryonic stem cell; Progenitor cell; Adult stem cell; Cellular differentiation; Immunology; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006574413,0.0001467095,0.0002516281,0.0000388627,0.0001686771,0.00001051357,0.0006375009,0.00006439345,0.0001229254],"category_scores_gemma":[0.00003002866,0.00007243311,0.00009046112,0.0001121854,0.000406241,0.000006550737,0.0001094697,0.0001931964,0.000006510547],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002481005,"about_ca_system_score_gemma":0.00004425947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004020608,"about_ca_topic_score_gemma":0.000001929429,"domain_scores_codex":[0.9983618,0.0001316364,0.0005387788,0.0001284132,0.0006001803,0.0002391423],"domain_scores_gemma":[0.9989716,0.00007769022,0.000279966,0.000384385,0.0001645501,0.0001218524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003681188,0.0001504975,0.0001036487,0.00001311391,0.00009500601,0.000006188641,0.0008496785,0.000003371636,0.9960116,0.00001066402,0.002171029,0.0002170844],"study_design_scores_gemma":[0.001465704,0.00142868,0.0002259479,0.00009474587,0.00002358239,0.0001636123,0.001561536,0.000007377023,0.993652,0.00001350476,0.001292283,0.00007105942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913346,0.006366848,0.00002823165,0.0006828036,0.0001488244,0.0001869764,0.000004569091,0.000001993248,0.001245133],"genre_scores_gemma":[0.9966983,0.0008864303,0.0000143572,0.00009258342,0.0003117914,0.000002603363,0.000001845615,0.00001857404,0.00197349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005480418,"threshold_uncertainty_score":0.2953736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02476536814459541,"score_gpt":0.3120244641585216,"score_spread":0.2872590960139262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}