{"id":"W2051436804","doi":"10.1016/j.ddmec.2008.01.002","title":"Endothelial activation and dysregulation: A common pathway to organ injury in infectious diseases associated with systemic inflammation","year":2007,"lang":"en","type":"article","venue":"Drug Discovery Today Disease Mechanisms","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Toronto General Hospital; University Health Network","funders":"","keywords":"Inflammation; Complement system; Systemic inflammation; Immunology; Organ dysfunction; Endothelial activation; Medicine; Endothelial dysfunction; Sepsis; Immune system; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004463761,0.0003422341,0.0004137485,0.0004228911,0.0002370752,0.0001048543,0.0001698951,0.0001031065,0.0001047649],"category_scores_gemma":[0.0003189424,0.0003120721,0.00007289049,0.0004432948,0.00006666662,0.0006169814,0.0001298822,0.0001407513,0.00004437018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003657442,"about_ca_system_score_gemma":0.0001606668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001063895,"about_ca_topic_score_gemma":0.0004442091,"domain_scores_codex":[0.9978852,0.0003715484,0.0005633275,0.0005254994,0.0001809417,0.0004735451],"domain_scores_gemma":[0.9987033,0.0003893709,0.0002848651,0.0003797936,0.0000910539,0.000151626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00669859,0.001483541,0.3704625,0.0004885328,0.0005476633,0.0001494691,0.002660273,0.00127875,0.5389495,0.06774051,0.000519932,0.009020783],"study_design_scores_gemma":[0.008370019,0.0006075219,0.7955861,0.002706776,0.0003925097,0.00003591324,0.002470271,0.0001195972,0.1776642,0.009893615,0.0005727054,0.001580773],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906469,0.0001507355,0.006195934,0.000154884,0.0003485826,0.001515203,0.0006526455,0.0002132678,0.0001218592],"genre_scores_gemma":[0.9980073,0.00000412803,0.00001038259,0.0001730298,0.00006179381,0.0001960402,0.001047306,0.00004501486,0.0004550052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4251236,"threshold_uncertainty_score":0.9999331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005281739538151982,"score_gpt":0.2184045147565254,"score_spread":0.2131227752183734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}