{"id":"W2051465499","doi":"10.1210/en.2014-1436","title":"Identification of Hot Spots of DNA Methylation in the Adult Male Adrenal in Response to In Utero Exposure to the Ubiquitous Endocrine Disruptor Plasticizer Di-(2-ethylhexyl) Phthalate","year":2014,"lang":"en","type":"article","venue":"Endocrinology","topic":"Effects and risks of endocrine disrupting chemicals","field":"Environmental Science","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; McGill University Health Centre; McGill University","keywords":"Phthalate; DNA methylation; Epigenetics; Offspring; Endocrinology; Endocrine disruptor; Biology; Internal medicine; Epigenomics; Benzhydryl compounds; Bisulfite sequencing; Methylation; In utero; Endocrine system; Gene expression; Fetus; Pregnancy; Genetics; Gene; Chemistry; Medicine; Bisphenol A; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006259853,0.0001109642,0.000159035,0.0003678733,0.00009105385,0.0001434109,0.0001168391,0.0001467683,0.001115381],"category_scores_gemma":[0.0001635606,0.0001300378,0.0001116322,0.0001963559,0.0001386184,0.00006753175,0.0001337546,0.0001770896,0.000137211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001112881,"about_ca_system_score_gemma":0.0001027431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00154736,"about_ca_topic_score_gemma":0.002842103,"domain_scores_codex":[0.9999442,0.0000051105,0.000001873981,0.0000216756,0.00001589914,0.00001127869],"domain_scores_gemma":[0.9998937,0.00001710763,0.00003509631,0.000009674,0.0000177026,0.00002674434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002180696,0.00001469808,0.01185594,0.00001967653,0.00002125926,0.00005259188,0.00006509533,0.00004898111,0.9834046,0.00003345661,0.00003735363,0.004228382],"study_design_scores_gemma":[0.00000877937,0.000238993,0.7867711,0.000004481678,0.00004305815,0.0003875951,0.000120096,0.0004013747,0.2109018,0.00009207465,0.001023029,0.000007571748],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959836,0.0007390436,0.002074476,0.00004256635,0.000008056667,0.00001055614,0.0005094392,0.00003333029,0.0005988272],"genre_scores_gemma":[0.9958055,0.000488078,0.001175686,0.00004250646,0.000008135323,0.00001505751,0.0005086269,0.00001109826,0.001945189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00154736,"threshold_uncertainty_score":0.00373131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008084222067003108,"score_gpt":0.3021253161199549,"score_spread":0.2940410940529518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}