{"id":"W2051469767","doi":"10.1016/j.molimm.2009.06.007","title":"C5a- and ASP-mediated C5L2 activation, endocytosis and recycling are lost in S323I-C5L2 mutation","year":2009,"lang":"en","type":"article","venue":"Molecular Immunology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Université Laval","funders":"Canada Research Chairs","keywords":"Transfection; Receptor; Cell biology; HEK 293 cells; Internalization; Phosphorylation; Endocytosis; Colocalization; Ligand (biochemistry); Biology; Molecular biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001547868,0.0001741805,0.0002022794,0.0001215092,0.00006793899,0.00003050562,0.00008758774,0.0002645898,0.00002683113],"category_scores_gemma":[0.0001944859,0.0001854671,0.00003746085,0.0001242061,0.00005703924,0.000009910309,0.00005594218,0.0001540227,0.000004801773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000191343,"about_ca_system_score_gemma":0.00002608053,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002009264,"about_ca_topic_score_gemma":0.000009262084,"domain_scores_codex":[0.9989011,0.0001165576,0.0002485785,0.0003968989,0.00007723177,0.0002595956],"domain_scores_gemma":[0.9995586,0.00002182141,0.0001194467,0.000192509,0.000062575,0.00004509957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007985704,0.0000349229,0.0005052892,0.00000611823,0.00003572869,0.00002567948,0.00007522172,0.00004218706,0.9915823,0.0002089841,0.00001836347,0.007385311],"study_design_scores_gemma":[0.001114634,0.0003916101,0.01289789,0.00003804354,0.00001360555,0.00006190091,0.0001975995,0.0001482062,0.9827052,0.0007834694,0.001409293,0.0002385467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915365,0.002774618,0.004671851,0.0005663634,0.00007063676,0.0001799279,0.000004241094,0.00001366157,0.0001822181],"genre_scores_gemma":[0.9977392,0.0005668002,0.0008574092,0.0006102804,0.00003447371,0.00001165766,0.0001191825,0.00001839276,0.00004259501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0123926,"threshold_uncertainty_score":0.7563128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005263659245022652,"score_gpt":0.217878763349251,"score_spread":0.2126151041042284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}