{"id":"W2051469767","doi":"10.1016/j.molimm.2009.06.007","title":"C5a- and ASP-mediated C5L2 activation, endocytosis and recycling are lost in S323I-C5L2 mutation","year":2009,"lang":"en","type":"article","venue":"Molecular Immunology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Université Laval","funders":"Canada Research Chairs","keywords":"Transfection; Receptor; Cell biology; HEK 293 cells; Internalization; Phosphorylation; Endocytosis; Colocalization; Ligand (biochemistry); Biology; Molecular biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002975888,0.001168205,0.0005601187,0.0008165049,0.0006650964,0.0005970473,0.001045841,0.001661142,0.00551137],"category_scores_gemma":[0.0004779718,0.0003808409,0.001075095,0.000415557,0.001389351,0.0004491073,0.0008149543,0.001393799,0.002648082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008438327,"about_ca_system_score_gemma":0.0005621364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003172763,"about_ca_topic_score_gemma":0.001808345,"domain_scores_codex":[0.99941,0.00008296342,0.00009208962,0.0001030525,0.0001918547,0.0001200404],"domain_scores_gemma":[0.9993187,0.00010611,0.0001928665,0.00009146331,0.00006319373,0.0002276922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003995264,0.00004915079,0.0002855866,0.00004041153,0.00002932609,0.001434447,0.00003325325,0.0001530807,0.9955645,0.0005488857,0.0002138649,0.001248029],"study_design_scores_gemma":[0.0001018389,0.0001342171,0.004259238,0.00001565893,0.00005565444,0.006284413,0.00007159296,0.003124761,0.9811353,0.0002958076,0.004488431,0.00003300251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821734,0.0006377379,0.009505937,0.0004716846,0.0002742837,0.00008862066,0.002087261,0.0005172011,0.004243727],"genre_scores_gemma":[0.9911918,0.0001727835,0.002889316,0.0001229625,0.00003082698,0.00007156572,0.0009502892,0.0002462871,0.004324174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00551137,"threshold_uncertainty_score":0.01843739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005263659245022652,"score_gpt":0.217878763349251,"score_spread":0.2126151041042284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}