{"id":"W2051474057","doi":"10.1158/1078-0432.tcmusa10-a53","title":"Abstract A53: Lovastatin inhibits EGFR dimerization and AKT activation in squamous cell carcinoma cells: Potential regulation through targeting rho proteins","year":2010,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"RHOA; Lovastatin; Gefitinib; Protein kinase B; PI3K/AKT/mTOR pathway; Cancer research; EGFR inhibitors; Epidermal growth factor receptor; Chemistry; Farnesyl pyrophosphate; Actin cytoskeleton; Geranylgeranyl pyrophosphate; Erlotinib; Farnesyltransferase inhibitor; Cell biology; Pharmacology; Signal transduction; Biology; Farnesyltransferase; Cell; Cytoskeleton; Biochemistry; Receptor; Prenylation; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001472545,0.000284487,0.0005079979,0.0002001817,0.0001772016,0.0003164529,0.0002010047,0.0002959788,0.002490624],"category_scores_gemma":[0.0001206349,0.00008892629,0.0002960872,0.000168828,0.0001478306,0.0001292258,0.0001132172,0.0004270497,0.0007055693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003188167,"about_ca_system_score_gemma":0.0003665709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001182747,"about_ca_topic_score_gemma":0.002552338,"domain_scores_codex":[0.999826,0.00003851832,0.00002448345,0.00002239905,0.00003533375,0.00005336932],"domain_scores_gemma":[0.9999424,0.000008699517,0.00001248875,0.000008664097,0.000008653006,0.00001899501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002987915,0.0005912955,0.000764641,0.0001034625,0.00004018969,0.00008587982,0.00001269646,0.000137896,0.9872357,0.00009350729,0.0004106438,0.007536181],"study_design_scores_gemma":[0.001081335,0.00713784,0.01563855,0.00001095514,0.00009825172,0.0004642323,0.00003713592,0.001347025,0.9681857,0.00006667416,0.005922406,0.000009885442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935136,0.003020985,0.0006227196,0.0001744489,0.00007655591,0.00008138321,0.0006652774,0.0001081602,0.001736901],"genre_scores_gemma":[0.9966208,0.0007090243,0.000406426,0.00005460103,0.00001528592,0.00003707076,0.0005555293,0.000008920159,0.001592285],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002490624,"threshold_uncertainty_score":0.008331895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04603905007341682,"score_gpt":0.3871271373972165,"score_spread":0.3410880873237997,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}