{"id":"W2051474400","doi":"10.1016/j.chembiol.2009.07.005","title":"A Promiscuous Ribozyme Promotes Nucleotide Synthesis in Addition to Ribose Chemistry","year":2009,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Ribozyme; Ribose; Hairpin ribozyme; Nucleotide; Biochemistry; Ligase ribozyme; Substrate (aquarium); Stereochemistry; Chemistry; RNA; Pyrophosphate; Biology; Combinatorial chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007031099,0.0005090073,0.0004854764,0.0002580276,0.0002833874,0.001025148,0.0005059986,0.0005289758,0.001332075],"category_scores_gemma":[0.0007831816,0.0003269322,0.0003184571,0.0002324589,0.0006734681,0.0008760042,0.0006744987,0.0009107423,0.0005997691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003706987,"about_ca_system_score_gemma":0.0003319375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007011058,"about_ca_topic_score_gemma":0.0001160255,"domain_scores_codex":[0.9996868,0.00005298971,0.00002886289,0.0001112531,0.00007588667,0.00004424029],"domain_scores_gemma":[0.9994696,0.0002052774,0.00006970311,0.0001135621,0.00003737413,0.0001044887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001897147,0.00004192129,0.0001621071,0.00004842153,0.000003407506,0.000151756,0.00002232367,0.0003437586,0.9880905,0.007769776,0.00006559998,0.003110644],"study_design_scores_gemma":[0.00001884423,0.0001379072,0.00008641182,0.000002592051,0.000005311469,0.0002118268,0.000005148739,0.001887429,0.9955801,0.0008988613,0.001159664,0.000005787106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9384159,0.001639342,0.04947641,0.0004241668,0.0003743892,0.00006747009,0.0001387865,0.0007889731,0.008674509],"genre_scores_gemma":[0.9866486,0.0003170467,0.01057645,0.00007975657,0.00005675612,0.00002423436,0.00006604181,0.00006721521,0.002163767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001332075,"threshold_uncertainty_score":0.004456222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007467848079099807,"score_gpt":0.23672001616787,"score_spread":0.2292521680887702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}