{"id":"W2051517149","doi":"10.1111/j.1747-0285.2009.00867.x","title":"Cyclic Opioid Peptide Agonists and Antagonists Obtained Via Ring‐Closing Metathesis","year":2009,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse","keywords":"Ring-closing metathesis; Closing (real estate); Cyclic peptide; Chemistry; Stereochemistry; Opioid; Peptide; Combinatorial chemistry; Opioid peptide; Metathesis; Pharmacology; Medicine; Receptor; Biochemistry; Organic chemistry; Business","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001893552,0.0005372367,0.0003468511,0.0001903318,0.0001318238,0.0002090983,0.0003974955,0.0003191835,0.002050308],"category_scores_gemma":[0.0001481054,0.0002641056,0.0003497492,0.000164351,0.0001368537,0.0002513739,0.0002450994,0.0005705016,0.0007841401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002679596,"about_ca_system_score_gemma":0.0001851304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002114819,"about_ca_topic_score_gemma":0.0004729044,"domain_scores_codex":[0.9998504,0.00001923161,0.00001137981,0.00003293322,0.0000302282,0.00005578257],"domain_scores_gemma":[0.9999456,0.000006426527,0.00002118984,0.00000827216,0.000007009733,0.00001143455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001838984,0.00002742027,0.00003636905,0.00006593062,0.00001414149,0.0000851307,0.00002082872,0.0001614503,0.9959891,0.0003206124,0.0001042602,0.002990784],"study_design_scores_gemma":[0.00008886911,0.001208626,0.0006151634,0.000008244268,0.00002850503,0.0002603469,0.00001113609,0.0004893884,0.9911979,0.00006864019,0.006008476,0.0000146939],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751517,0.004438607,0.007936644,0.0002267563,0.0001684246,0.0002270212,0.0006152319,0.0002709219,0.0109647],"genre_scores_gemma":[0.9859421,0.002381064,0.006868928,0.0001528639,0.00006027787,0.0001208695,0.0005169088,0.00005845408,0.003898563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002050308,"threshold_uncertainty_score":0.006858945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009445725114324843,"score_gpt":0.2433724455616587,"score_spread":0.2339267204473339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}