{"id":"W2051517149","doi":"10.1111/j.1747-0285.2009.00867.x","title":"Cyclic Opioid Peptide Agonists and Antagonists Obtained Via Ring‐Closing Metathesis","year":2009,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse","keywords":"Ring-closing metathesis; Closing (real estate); Cyclic peptide; Chemistry; Stereochemistry; Opioid; Peptide; Combinatorial chemistry; Opioid peptide; Metathesis; Pharmacology; Medicine; Receptor; Biochemistry; Organic chemistry; Business","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003163399,0.0003534094,0.0004843553,0.0000534072,0.0001415961,0.00004525122,0.0003139832,0.0003321302,0.00003033805],"category_scores_gemma":[0.0002532766,0.0003047481,0.000243046,0.0001473995,0.0002997235,0.00000646426,0.0001143468,0.0001753808,0.00001681886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003067033,"about_ca_system_score_gemma":0.00003432743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000111987,"about_ca_topic_score_gemma":9.876172e-7,"domain_scores_codex":[0.9980635,0.000134724,0.0003837114,0.0007995151,0.00009911876,0.0005194335],"domain_scores_gemma":[0.9990406,0.0001213901,0.0001313188,0.0004108667,0.00005795611,0.0002378592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008887803,0.00009574695,0.0004090773,0.000008824094,0.0001152378,0.00000485899,0.00002384553,0.000001834368,0.9772249,0.00006078049,0.0008824178,0.02108358],"study_design_scores_gemma":[0.0003934605,0.00007888388,0.000240628,0.00001446046,0.0001257334,0.00002800126,0.00001426087,0.0001325818,0.9878719,0.002049924,0.008662827,0.0003872648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880539,0.002624603,0.007086103,0.001283744,0.0000429627,0.0001757108,0.00001260538,0.00005604972,0.0006642962],"genre_scores_gemma":[0.9908029,0.0004458074,0.007040562,0.00102532,0.0002865188,0.00001787847,0.0001428733,0.0000248394,0.0002132372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02069632,"threshold_uncertainty_score":0.9999405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009445725114324843,"score_gpt":0.2433724455616587,"score_spread":0.2339267204473339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}