{"id":"W2051543844","doi":"10.1021/ol4030937","title":"Total Synthesis of (+)-Cassaine Utilizing an Anionic Polycyclization Strategy","year":2013,"lang":"en","type":"article","venue":"Organic Letters","topic":"Natural product bioactivities and synthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Université de Sherbrooke","funders":"","keywords":"Chemistry; Stereoselectivity; Natural product; Total synthesis; Stereochemistry; Sequence (biology); Combinatorial chemistry; Organic chemistry; Catalysis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001215942,0.0004118169,0.0002829293,0.0002606689,0.000271753,0.0003127103,0.0002272441,0.0001999404,0.002221073],"category_scores_gemma":[0.0001004626,0.000154743,0.0002693677,0.0002875367,0.0002022653,0.0002646683,0.0003484933,0.0005192964,0.001254713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002791247,"about_ca_system_score_gemma":0.0006329028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005330233,"about_ca_topic_score_gemma":0.001123972,"domain_scores_codex":[0.9998665,0.00001558518,0.00001418434,0.00003657116,0.00002937886,0.00003787327],"domain_scores_gemma":[0.9999387,0.000006241241,0.0000115593,0.00001225811,0.00001735566,0.00001384313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001064858,0.00004901698,0.000147793,0.0002592172,0.00002138695,0.0005140795,0.00009096994,0.0007604663,0.9702671,0.004913403,0.0005407094,0.02232936],"study_design_scores_gemma":[0.00002439614,0.0006114929,0.0006964623,0.00001620337,0.00002651335,0.0006796274,0.00002507066,0.000597076,0.9632506,0.00045308,0.03359408,0.00002540145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8538849,0.005496544,0.08252117,0.0003459269,0.0004465562,0.0004999737,0.00164464,0.001054869,0.05410539],"genre_scores_gemma":[0.9410121,0.004376304,0.03562692,0.0001276167,0.00005465379,0.0002029818,0.0007375455,0.0001136008,0.01774833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002221073,"threshold_uncertainty_score":0.007430255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00869507647732807,"score_gpt":0.2147464305847462,"score_spread":0.2060513541074181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}