{"id":"W2051547341","doi":"10.1124/jpet.107.123422","title":"B-9972 (D-Arg-[Hyp3,Igl5,Oic7,Igl8]-bradykinin) Is an Inactivation-Resistant Agonist of the Bradykinin B2 Receptor Derived from the Peptide Antagonist B-9430 (D-Arg-[Hyp3,Igl5,D-Igl7,Oic8]-bradykinin): Pharmacologic Profile and Effective Induction of Receptor Degradation","year":2007,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre hospitalier universitaire de Québec","funders":"","keywords":"Bradykinin; Bradykinin receptor; Receptor; Agonist; Chemistry; Molecular biology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001473323,0.0005385831,0.000301081,0.000259012,0.0001879956,0.0002430307,0.0003452251,0.0004355386,0.001714265],"category_scores_gemma":[0.0001698403,0.0001814984,0.0002223831,0.0001756936,0.0002799875,0.0002609877,0.0001448414,0.0009186136,0.001155573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002114462,"about_ca_system_score_gemma":0.0001724964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004057397,"about_ca_topic_score_gemma":0.0004569821,"domain_scores_codex":[0.9998618,0.00002190476,0.000009327288,0.00001697823,0.00003340807,0.00005660344],"domain_scores_gemma":[0.999911,0.00001274504,0.00003212463,0.000008024718,0.000004038435,0.00003207357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009224057,0.0001618277,0.000154403,0.00005566024,0.00001244734,0.0002662913,0.00001271072,0.0001279695,0.9881321,0.0001985338,0.0002533454,0.009702274],"study_design_scores_gemma":[0.0003819399,0.002621804,0.003198631,0.000007826493,0.00002444127,0.003386513,0.00001583506,0.0006650619,0.9829968,0.00006296502,0.006623389,0.00001478382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848323,0.005338921,0.004185552,0.0001943057,0.00005101899,0.000106201,0.0005257971,0.000223269,0.004542571],"genre_scores_gemma":[0.9911144,0.001845008,0.003238817,0.0001027594,0.00003084169,0.00006071285,0.001057092,0.0000297444,0.002520574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001714265,"threshold_uncertainty_score":0.005734742,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03211259373119493,"score_gpt":0.3326645159493282,"score_spread":0.3005519222181333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}