{"id":"W2051548413","doi":"10.3851/imp1839","title":"Next-Generation Sequencing of Dried Blood Spot Specimens: A Novel Approach to HIV Drug-Resistance Surveillance","year":2011,"lang":"en","type":"article","venue":"Antiviral Therapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"","keywords":"Sanger sequencing; Dried blood spot; Pyrosequencing; Genotyping; Multiplex; DNA sequencing; Dried blood; Human immunodeficiency virus (HIV); Drug resistance; Medicine; HIV drug resistance; Genotype; Virology; Biology; Genetics; Viral load; DNA; Gene; Antiretroviral therapy; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001120612,0.0004948966,0.000652652,0.001386213,0.0002616784,0.0007364355,0.0006788542,0.0008415242,0.0007739338],"category_scores_gemma":[0.001471461,0.0003598183,0.0003929632,0.0008654593,0.0004013414,0.0005540343,0.0005437552,0.0007570992,0.0005176105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003700587,"about_ca_system_score_gemma":0.0003119385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005984115,"about_ca_topic_score_gemma":0.001307749,"domain_scores_codex":[0.9988629,0.0002762898,0.00005242516,0.0003489394,0.0004237806,0.00003570914],"domain_scores_gemma":[0.9992558,0.0002418761,0.0002071784,0.0001036742,0.0001477494,0.0000436984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002340664,0.0001197612,0.007848345,0.000460747,0.0002259337,0.0002233805,0.0001632014,0.002041201,0.8210677,0.0009744093,0.001482446,0.1651589],"study_design_scores_gemma":[0.0001373546,0.001505095,0.0577414,0.0003129858,0.0005654338,0.006546551,0.0002573331,0.1096038,0.7597821,0.00672799,0.05660461,0.0002153979],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2866656,0.01760463,0.6814973,0.001252782,0.0005951796,0.0004890445,0.003499142,0.00241082,0.005985511],"genre_scores_gemma":[0.283197,0.006074429,0.7041121,0.001172485,0.0004206662,0.0002910726,0.001609101,0.0001319116,0.002991349],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001386213,"threshold_uncertainty_score":0.00592643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.100910964377377,"score_gpt":0.2592985268608887,"score_spread":0.1583875624835118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}