{"id":"W2051548413","doi":"10.3851/imp1839","title":"Next-Generation Sequencing of Dried Blood Spot Specimens: A Novel Approach to HIV Drug-Resistance Surveillance","year":2011,"lang":"en","type":"article","venue":"Antiviral Therapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Public Health Agency of Canada","funders":"","keywords":"Sanger sequencing; Dried blood spot; Pyrosequencing; Genotyping; Multiplex; DNA sequencing; Dried blood; Human immunodeficiency virus (HIV); Drug resistance; Medicine; HIV drug resistance; Genotype; Virology; Biology; Genetics; Viral load; DNA; Gene; Antiretroviral therapy; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002478787,0.000218759,0.0003929557,0.0001184586,0.00006735184,0.00001511866,0.0001059929,0.00005459416,0.00004435159],"category_scores_gemma":[0.00001428428,0.0001790607,0.00009606733,0.0003194261,0.00005170999,0.0001193805,0.00001848093,0.00008307152,0.00003961313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005734631,"about_ca_system_score_gemma":0.0001043563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002727564,"about_ca_topic_score_gemma":0.0000478619,"domain_scores_codex":[0.9987266,0.00004272392,0.0003291584,0.0003615002,0.0002690204,0.0002709988],"domain_scores_gemma":[0.9993666,0.0000224197,0.000113565,0.0003197484,0.000102331,0.00007528206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006897809,0.001462822,0.03613386,0.00004899175,0.0004519441,0.00003140332,0.00945102,0.000001699847,0.944649,0.002449856,0.002661121,0.001968438],"study_design_scores_gemma":[0.005470967,0.0001323606,0.02572402,0.000118112,0.00005789055,0.00001224564,0.0004257895,0.000152107,0.9618413,0.00007255159,0.005578807,0.0004138369],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745885,0.0004168884,0.001391459,0.0004635701,0.00008027843,0.0006387351,0.00001205343,0.00005925753,0.02234928],"genre_scores_gemma":[0.9492801,0.0002060603,0.03161063,0.000180475,0.0001288467,0.00003881477,0.00006433221,0.00003079357,0.01845993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03021917,"threshold_uncertainty_score":0.7301882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.100910964377377,"score_gpt":0.2592985268608887,"score_spread":0.1583875624835118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}