{"id":"W2051554474","doi":"10.3109/09687681003588020","title":"Impaired trafficking and intracellular retention of mutant kidney anion exchanger 1 proteins (G701D and A858D) associated with distal renal tubular acidosis","year":2010,"lang":"en","type":"article","venue":"Molecular Membrane Biology","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Faculty of Medicine Siriraj Hospital, Mahidol University; Canadian Institutes of Health Research; Thailand Research Fund","keywords":"HEK 293 cells; Distal renal tubular acidosis; Biology; Mutant; Renal tubular acidosis; Intercalated Cell; Kidney; Cell biology; Wild type; Nephron; Intracellular; Epithelial polarity; Molecular biology; Cell; Cell culture; Genetics; Gene; Metabolic acidosis; Acidosis; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000274135,0.0002199321,0.000254983,0.00007764907,0.00008217538,0.00001463691,0.00008511884,0.0003988442,0.00001759835],"category_scores_gemma":[0.00007739908,0.0001887663,0.00007190819,0.0001074096,0.0002731027,0.000008581172,0.00003858074,0.0001502003,2.883889e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006865292,"about_ca_system_score_gemma":0.00004642881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001995902,"about_ca_topic_score_gemma":0.00005285392,"domain_scores_codex":[0.998822,0.0000964096,0.0002614133,0.0004427358,0.0001146823,0.0002627879],"domain_scores_gemma":[0.9993628,0.000007041079,0.0001693546,0.0002203809,0.0001075799,0.0001328249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002229815,0.00006439861,0.002040077,0.00005080696,0.0001104869,0.00001538533,0.00009640939,0.00000621136,0.9960592,0.000193199,0.000003596908,0.001137268],"study_design_scores_gemma":[0.001214878,0.0008578927,0.004807203,0.00005120561,0.00008545997,0.00005123415,0.00004360967,0.0002337858,0.9916909,0.00005061226,0.0006664141,0.0002467518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949718,0.000353057,0.003989253,0.0001262883,0.00009804673,0.0003651346,0.00004835416,0.00002177194,0.00002629112],"genre_scores_gemma":[0.9981395,0.00007833622,0.0004524961,0.00005032135,0.00007246293,0.00002813377,0.001118738,0.00003062931,0.00002940061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004368225,"threshold_uncertainty_score":0.7697665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005550769843832576,"score_gpt":0.196536217589906,"score_spread":0.1909854477460735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}