{"id":"W2051554474","doi":"10.3109/09687681003588020","title":"Impaired trafficking and intracellular retention of mutant kidney anion exchanger 1 proteins (G701D and A858D) associated with distal renal tubular acidosis","year":2010,"lang":"en","type":"article","venue":"Molecular Membrane Biology","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Faculty of Medicine Siriraj Hospital, Mahidol University; Canadian Institutes of Health Research; Thailand Research Fund","keywords":"HEK 293 cells; Distal renal tubular acidosis; Biology; Mutant; Renal tubular acidosis; Intercalated Cell; Kidney; Cell biology; Wild type; Nephron; Intracellular; Epithelial polarity; Molecular biology; Cell; Cell culture; Genetics; Gene; Metabolic acidosis; Acidosis; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001427403,0.00093812,0.000557815,0.0005868439,0.0003844249,0.0003364939,0.00035762,0.001034001,0.0007385957],"category_scores_gemma":[0.0004523609,0.0003312088,0.0004128823,0.0003747284,0.0006247947,0.000284522,0.0004644861,0.0005735718,0.000238589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002573482,"about_ca_system_score_gemma":0.0001852685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008005049,"about_ca_topic_score_gemma":0.0005469746,"domain_scores_codex":[0.9997525,0.00002785276,0.00003973881,0.00008717649,0.00005024496,0.00004256251],"domain_scores_gemma":[0.999767,0.00004961955,0.00008562589,0.00001373506,0.0000153667,0.0000686998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00143666,0.0002119338,0.05421124,0.0001588814,0.0001327947,0.07546387,0.0006200027,0.000779479,0.8616318,0.0005029192,0.0002824664,0.004567985],"study_design_scores_gemma":[0.000346218,0.001487903,0.3743141,0.00003441779,0.0004005413,0.3999493,0.0005700046,0.006939712,0.2119026,0.0005922423,0.003363779,0.00009919053],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991229,0.0001418769,0.0004806648,0.00004091653,0.000006932673,0.00000586843,0.00007332541,0.00001768312,0.0001099473],"genre_scores_gemma":[0.9991003,0.0001328043,0.0003943061,0.00003357265,0.00001098234,0.000006409457,0.0001175022,0.000008701089,0.0001953997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001034001,"threshold_uncertainty_score":0.002470851,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005550769843832576,"score_gpt":0.196536217589906,"score_spread":0.1909854477460735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}