{"id":"W2051572255","doi":"10.1096/fj.03-1436fje","title":"Amyloidogenesis recapitulated in cell culture: a peptide inhibitor provides direct evidence for the role of heparan sulfate and suggests a new treatment strategy","year":2004,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston General Hospital; Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Heparan sulfate; Chemistry; Serum amyloid A; Amyloid (mycology); Peptide; Biochemistry; Fibril; Amyloid disease; Cell biology; Heparin; Biology; Immunology; Amyloid β; Inflammation; Internal medicine; Amyloid fibril; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003079101,0.0002536254,0.0002620686,0.00004623766,0.0001973152,0.00006793231,0.0002380268,0.0001048168,0.000006377547],"category_scores_gemma":[0.0001040283,0.0001345038,0.0001895387,0.0001177665,0.000110819,0.00001661493,0.00005306813,0.00009613455,0.000001865274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001023567,"about_ca_system_score_gemma":0.0003036978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007101402,"about_ca_topic_score_gemma":0.0007854485,"domain_scores_codex":[0.998786,0.0001199666,0.0003495855,0.0002683612,0.0001442989,0.0003317831],"domain_scores_gemma":[0.9991236,0.0001417109,0.00025108,0.0002947323,0.00007019854,0.0001187187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006633996,0.0002269186,0.03367009,0.00001632725,0.000244125,0.00001031079,0.0008988776,0.001983824,0.9545473,0.00001663488,0.0001696905,0.007552492],"study_design_scores_gemma":[0.00259322,0.001293843,0.01050263,0.0001088026,0.000219228,0.00008141652,0.0006470222,0.00003060104,0.9832003,0.0002488829,0.0009095729,0.0001645551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9618919,0.03664653,0.00004693054,0.0005974687,0.00005206663,0.0006793971,0.00002561987,0.000007015373,0.00005302786],"genre_scores_gemma":[0.9868559,0.01206985,0.0003402116,0.00007909086,0.000187035,0.00008425934,0.0000087742,0.00002509322,0.0003498183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02865292,"threshold_uncertainty_score":0.5484906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02414506170400227,"score_gpt":0.2797495715247571,"score_spread":0.2556045098207548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}