{"id":"W2051578254","doi":"10.1016/j.bmcl.2008.03.067","title":"N-Acetylhexosaminidase inhibitory properties of C-1 homologated GlcNAc- and GalNAc-thiazolines","year":2008,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Chemistry; Stereochemistry; Pyranose; Steric effects; Anomer; Thiazole; Substrate (aquarium); Thiazoline","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001872514,0.0002493343,0.0002123902,0.0001867259,0.0001157026,0.0001686999,0.0003298667,0.0001636236,0.001336111],"category_scores_gemma":[0.0002746219,0.0001224839,0.0001348721,0.0001406157,0.0002049459,0.0001421391,0.0001537571,0.0003542816,0.000229796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002330881,"about_ca_system_score_gemma":0.0001607079,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001301728,"about_ca_topic_score_gemma":0.001240028,"domain_scores_codex":[0.9999118,0.00003043277,0.000007591283,0.00001005603,0.00001404189,0.00002601735],"domain_scores_gemma":[0.999887,0.00002750814,0.00002256345,0.0000108321,0.00001765322,0.00003453447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002468828,0.00008394577,0.0004574062,0.000128383,0.0000247715,0.0002152244,0.0001061623,0.0009275939,0.98926,0.0002765724,0.0002405604,0.00581053],"study_design_scores_gemma":[0.0001796312,0.003347056,0.002428967,0.00001205054,0.00003518032,0.0003083968,0.00004864047,0.001820292,0.989061,0.00003948477,0.00270026,0.00001914887],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962338,0.001548687,0.0004267731,0.00004551917,0.00002518669,0.00001136448,0.0001291986,0.00002933637,0.001550353],"genre_scores_gemma":[0.9968333,0.0009006422,0.0003945997,0.00002723028,0.000009654688,0.00000761959,0.0001750087,0.00000767845,0.001644408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001336111,"threshold_uncertainty_score":0.004469693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02062544237441491,"score_gpt":0.1811850878150748,"score_spread":0.1605596454406599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}