{"id":"W2051643304","doi":"10.1038/clpt.2013.178","title":"Challenges in Interpreting the Evidence for Genetic Predictors of Ototoxicity","year":2013,"lang":"en","type":"letter","venue":"Clinical Pharmacology & Therapeutics","topic":"Hearing, Cochlea, Tinnitus, Genetics","field":"Neuroscience","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; National Institute of General Medical Sciences; University of British Columbia; Genome Canada","keywords":"Ototoxicity; Clinical pharmacology; Psychology; Medicine; Pharmacology; Internal medicine; Cisplatin","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.07681199,0.001046466,0.003261372,0.003563237,0.002193711,0.005174808,0.005574625,0.01300224,0.003164466],"category_scores_gemma":[0.349543,0.0008339878,0.002161385,0.00287268,0.008560985,0.007922054,0.002754819,0.02349523,0.003342232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002696839,"about_ca_system_score_gemma":0.004035626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004781132,"about_ca_topic_score_gemma":0.005256215,"domain_scores_codex":[0.9410139,0.0324383,0.01168973,0.004076391,0.009781085,0.001000624],"domain_scores_gemma":[0.4636264,0.4841851,0.01370603,0.008631466,0.02755965,0.002291332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001331332,0.0002522925,0.06607807,0.004689267,0.002403267,0.01448024,0.00219827,0.001077815,0.001707078,0.03597499,0.5657555,0.3040519],"study_design_scores_gemma":[0.0009224294,0.0007271378,0.05115558,0.01275039,0.00222585,0.0280425,0.005181109,0.005635288,0.002079016,0.4537163,0.4369536,0.0006107883],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.002875815,0.03164917,0.003155457,0.9391285,0.01996671,0.00003741042,0.0003784086,0.00007993083,0.002728608],"genre_scores_gemma":[0.05086797,0.02547143,0.008894455,0.7619322,0.1513112,0.0001634215,0.0002486703,0.00009538568,0.001015229],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.07681199,"threshold_uncertainty_score":0.4062255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4914424834688712,"score_gpt":0.4881609874147897,"score_spread":0.003281496054081456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}