{"id":"W2051683789","doi":"10.1073/pnas.0807627105","title":"α1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice","year":2008,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":189,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health","keywords":"FOXP3; Islet; Transplantation; Immune system; Immune tolerance; Immunology; Proinflammatory cytokine; Cytokine; Population; Antigen; Cytotoxic T cell; Pancreatic islets; Biology; Medicine; Endocrinology; Internal medicine; Diabetes mellitus; Inflammation; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000398576,0.0006997494,0.0006792959,0.0006855041,0.0002756305,0.0005234106,0.000334314,0.0005495025,0.0009656943],"category_scores_gemma":[0.0001935622,0.0003377694,0.0006655256,0.0002915829,0.0004154635,0.0003656794,0.0002420627,0.001788226,0.0004284499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002540294,"about_ca_system_score_gemma":0.0002996041,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002607703,"about_ca_topic_score_gemma":0.0004840864,"domain_scores_codex":[0.9994848,0.00009324576,0.00006758725,0.0001169805,0.0001046853,0.0001326348],"domain_scores_gemma":[0.9995961,0.00004357746,0.0001263885,0.00005661069,0.00002344655,0.0001539077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009142388,0.0005418091,0.0002515306,0.00003692434,0.00001355048,0.00007416399,0.00003388578,0.00006913002,0.996753,0.00006229946,0.0000434793,0.001205916],"study_design_scores_gemma":[0.0003692533,0.01299624,0.005760331,0.00002831281,0.00009335794,0.0004510771,0.00006697102,0.001174655,0.9771308,0.0001122906,0.001800576,0.00001626369],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971713,0.0006411081,0.0008860696,0.00006954197,0.00006338,0.00006253041,0.000196972,0.00009213859,0.0008170579],"genre_scores_gemma":[0.9939265,0.0008468846,0.001478206,0.0001500038,0.00005305982,0.0001501982,0.0005278146,0.00004870301,0.002818689],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009656943,"threshold_uncertainty_score":0.003230512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03563256917133625,"score_gpt":0.2888546172171645,"score_spread":0.2532220480458283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}