{"id":"W2051688017","doi":"10.1248/cpb.58.301","title":"Antimicrobial and Antileishmanial Studies of Novel (2E)-3-(2-Chloro-6-methyl/methoxyquinolin-3-yl)-1-(Aryl)prop-2-en-1-ones","year":2010,"lang":"en","type":"article","venue":"Chemical and Pharmaceutical Bulletin","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Directorate for Biological Sciences; Higher Education Commission, Pakistan; University of Karachi; University of the Punjab","keywords":"Chemistry; Antimicrobial; Antifungal; Stereochemistry; Aryl; Antibacterial activity; Medicinal chemistry; Organic chemistry; Bacteria; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004394457,0.0003708694,0.0007065886,0.00003354738,0.0001135339,0.00003890611,0.0002435727,0.0004515012,0.002054268],"category_scores_gemma":[0.0009688413,0.0002646055,0.0001465753,0.00008539554,0.001278193,0.00004241706,0.0004752665,0.0009131355,0.00001337966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001203348,"about_ca_system_score_gemma":0.0000159546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001525156,"about_ca_topic_score_gemma":7.612292e-7,"domain_scores_codex":[0.9981567,0.00003542277,0.0004721017,0.0006582662,0.0002099719,0.0004675117],"domain_scores_gemma":[0.9977759,0.001476903,0.0001286403,0.0002144793,0.0001057594,0.0002983608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003448205,0.0005696863,0.002724627,0.0004544616,0.0001030129,0.000009657458,0.0000606357,6.197767e-8,0.9777316,0.0002834946,0.0008878022,0.01683016],"study_design_scores_gemma":[0.001204435,0.00003198802,0.0004187041,0.00007127212,0.00009164443,0.00008895271,0.00005786536,0.00006981073,0.9556832,0.0001427771,0.04177733,0.0003619913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946579,0.0007017255,0.0000121315,0.00278203,0.0001877696,0.0001040745,0.0001006491,0.00006581254,0.001387855],"genre_scores_gemma":[0.9950351,0.0009610019,0.002837735,0.0003629717,0.0006401608,0.00001272188,0.00001455256,0.00002226684,0.0001135091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04088952,"threshold_uncertainty_score":0.9999806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05261279348790144,"score_gpt":0.331757889118821,"score_spread":0.2791450956309195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}