{"id":"W2051688017","doi":"10.1248/cpb.58.301","title":"Antimicrobial and Antileishmanial Studies of Novel (2E)-3-(2-Chloro-6-methyl/methoxyquinolin-3-yl)-1-(Aryl)prop-2-en-1-ones","year":2010,"lang":"en","type":"article","venue":"Chemical and Pharmaceutical Bulletin","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Directorate for Biological Sciences; Higher Education Commission, Pakistan; University of Karachi; University of the Punjab","keywords":"Chemistry; Antimicrobial; Antifungal; Stereochemistry; Aryl; Antibacterial activity; Medicinal chemistry; Organic chemistry; Bacteria; Microbiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001549246,0.000360113,0.0003337128,0.0003935336,0.0001483335,0.0001756081,0.0002650827,0.000190952,0.001167243],"category_scores_gemma":[0.0001483686,0.0001265102,0.0001498074,0.0002263998,0.0002178032,0.0001731929,0.0001430685,0.0001681306,0.0002314627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001610042,"about_ca_system_score_gemma":0.000266231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005528951,"about_ca_topic_score_gemma":0.001801266,"domain_scores_codex":[0.999912,0.00002083907,0.000009563986,0.00001359672,0.00002551138,0.00001842932],"domain_scores_gemma":[0.9999008,0.00001013606,0.00002027272,0.000005539796,0.00002730377,0.00003590724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004185523,0.0001459334,0.0005171717,0.0002873742,0.00001901932,0.0002626888,0.00003862117,0.0004644835,0.9917779,0.0001261097,0.00008196502,0.005860223],"study_design_scores_gemma":[0.000315214,0.00884612,0.01383341,0.00004220336,0.00008671617,0.0008540828,0.00008562599,0.001336852,0.9681624,0.000104553,0.006298783,0.00003403207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925936,0.005066813,0.0007735476,0.00007142526,0.00002054389,0.00006597679,0.0002869038,0.00002954387,0.001091525],"genre_scores_gemma":[0.9938545,0.002968782,0.001279575,0.00007075429,0.000020322,0.00003455887,0.0005222725,0.000005780349,0.001243449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001167243,"threshold_uncertainty_score":0.003904819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05261279348790144,"score_gpt":0.331757889118821,"score_spread":0.2791450956309195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}