{"id":"W2051736421","doi":"10.1073/pnas.0904817106","title":"Mutation I810N in the α3 isoform of Na <sup>+</sup> ,K <sup>+</sup> -ATPase causes impairments in the sodium pump and hyperexcitability in the CNS","year":2009,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; Novo Nordisk Fonden; H. Lundbeck A/S; Lundbeckfonden; Sundhed og Sygdom, Det Frie Forskningsråd; Danmarks Grundforskningsfond; National Research Foundation; Medical Research Council; Novo Nordisk; Royal Society; National Alliance for Research on Schizophrenia and Depression","keywords":"Gene isoform; Hippocampal formation; Mutant; Mutagenesis; Hippocampus; Mutation; Chemistry; Molecular biology; Epilepsy; Biochemistry; Biology; Neuroscience; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002681616,0.000110878,0.0001243905,0.0001118613,0.0001248626,0.00002401999,0.0006711932,0.0001129049,0.000003065181],"category_scores_gemma":[0.000220047,0.00005571702,0.00006114555,0.0005854518,0.0004950209,0.00006410046,0.00003063165,0.00015745,1.573533e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001725143,"about_ca_system_score_gemma":0.00004173043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003752606,"about_ca_topic_score_gemma":0.000003339296,"domain_scores_codex":[0.9984562,0.00003660776,0.0003836238,0.0002300104,0.0007254551,0.0001680693],"domain_scores_gemma":[0.99955,0.00007920582,0.0002078566,0.00002774416,0.0001211735,0.00001394661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000756357,0.002168845,0.4858006,0.0005504231,0.00006560842,7.95045e-7,0.07769107,0.01991547,0.3888984,0.01775524,0.0006337268,0.005763463],"study_design_scores_gemma":[0.0006541385,0.0002770623,0.8916391,0.00006771875,0.00001590644,0.00002555502,0.0122244,0.006152665,0.06965759,0.0190861,0.00007886832,0.0001208748],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938766,0.0001114293,0.000001332433,0.005182884,0.000005260417,0.0003769837,0.00001353551,0.000001770666,0.0004302429],"genre_scores_gemma":[0.9992091,0.00005363227,0.00005087232,0.0005991604,0.00005041277,0.00002062568,0.000003707735,0.000002463253,0.00001002148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4058385,"threshold_uncertainty_score":0.2272074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0218218462664996,"score_gpt":0.2793861550259992,"score_spread":0.2575643087594996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}