{"id":"W2051766214","doi":"10.2174/1875397300801010002","title":"The Use of AlphaScreen Technology in HTS: Current Status","year":2008,"lang":"en","type":"article","venue":"Current Chemical Genomics","topic":"bioluminescence and chemiluminescence research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":257,"is_retracted":false,"has_abstract":true,"ca_institutions":"PerkinElmer Biosignal","funders":"","keywords":"Chemistry; Peptide; Small molecule; Analyte; Protein kinase A; Phosphorylation; High-throughput screening; G protein-coupled receptor; Biophysics; Combinatorial chemistry; Biochemistry; Signal transduction; Biology; Chromatography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009730097,0.0001689772,0.0001868157,0.00006672114,0.00007046231,0.00001198946,0.0004292286,0.0001724435,0.00000338755],"category_scores_gemma":[0.0002725795,0.0001329371,0.00009431902,0.0002964029,0.000661505,0.000007471431,0.000319922,0.0003158873,0.000006960578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005487659,"about_ca_system_score_gemma":0.0002160482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001197178,"about_ca_topic_score_gemma":0.000007117336,"domain_scores_codex":[0.9985449,0.00002327968,0.000371182,0.0003528227,0.000171172,0.0005366054],"domain_scores_gemma":[0.9991378,0.00003489852,0.00009969519,0.0004783194,0.0001392745,0.0001099768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009565008,0.0001871131,0.03028975,0.00003230782,0.00001336784,0.000001651652,0.00003127169,0.00000260205,0.9019358,0.00005862854,0.002295602,0.06505621],"study_design_scores_gemma":[0.0003737066,0.00003844968,0.0004350265,0.00002841425,0.000004555965,0.00001120336,0.00003061921,0.00006725785,0.6713245,0.00005572618,0.3274778,0.0001527802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866251,0.0126652,0.0001425822,0.0001669453,0.0001459819,0.0001950977,0.00002835123,0.000009457722,0.00002128885],"genre_scores_gemma":[0.9711385,0.02808518,0.0003374432,0.00001260919,0.0001773197,0.00003854963,0.0001451401,0.00002007486,0.00004520034],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3251821,"threshold_uncertainty_score":0.5421018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06822557031337118,"score_gpt":0.3083438976000442,"score_spread":0.240118327286673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}